Front. Pharmacol. Frontiers in Pharmacology Front. Pharmacol. 1663-9812 Frontiers Media S.A. 1734058 10.3389/fphar.2025.1734058 Correction Correction: Mitochondrial iron overload-mediated inhibition of Nrf2-HO-1/GPX4 assisted ALI-induced nephrotoxicity Deng et al. 10.3389/fphar.2025.1734058 Deng Hui-Fang 1 † Writing - review and editing Writing - original draft Investigation Yue Lan-Xin 1 † Investigation Writing - original draft Formal Analysis Methodology Wang Ning-Ning 1 2 † Writing - original draft Writing - review and editing Zhou Yong-Qiang 1 † Writing - original draft Zhou Wei 1 Project administration Writing - review and editing Conceptualization Supervision Liu Xian 1 Writing - review and editing Ni Yu-Hao 1 Validation Methodology Writing - original draft Investigation Huang Cong-Shu 1 3 Formal Analysis Investigation Writing - original draft Data curation Methodology Qiu Li-Zhen 1 2 Data curation Methodology Investigation Formal Analysis Writing - review and editing Liu Hong 1 3 Writing - review and editing Writing - original draft Tan Hong-Ling 1 Supervision Writing - review and editing Methodology Tang Xiang-Lin 1 Writing - review and editing Methodology Supervision Wang Yu-Guang 1 Writing - review and editing Supervision Methodology Ma Zeng-Chun 1 Writing - review and editing Methodology Supervision Gao Yue 1 2 * Resources Funding acquisition Conceptualization Writing - review and editing Project administration Supervision Department of Pharmaceutical Sciences, Beijing Institute of Radiation Medicine, Beijing, China Tianjin University of Traditional Chinese Medicine, Tianjin, China School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou, China Correspondence: Yue Gao, gaoyue@bmi.ac.cn

These authors have contributed equally to this work

 15 12 2025 2025 16 1734058 28 10 2025 28 11 2025 Copyright © 2025 Deng, Yue, Wang, Zhou, Zhou, Liu, Ni, Huang, Qiu, Liu, Tan, Tang, Wang, Ma and Gao. 2025 Deng, Yue, Wang, Zhou, Zhou, Liu, Ni, Huang, Qiu, Liu, Tan, Tang, Wang, Ma and Gao https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. A Correction on Mitochondrial Iron Overload-Mediated Inhibition of Nrf2-HO-1/GPX4 Assisted ALI-Induced Nephrotoxicity by Deng H-F, Yue L-X, Wang N-N, Zhou Y-Q, Zhou W, Liu X, Ni Y-H, Huang C-S, Qiu L-Z, Liu H, Tan H-L, Tang X-L, Wang Y-G, Ma Z-C and Gao Y (2021). Front. Pharmacol. 11:624529. doi: 10.3389/fphar.2020.624529 aristolactam I nephrotoxicity ferroptosis mitochondrial iron overload Nrf2-HO-1/GPX4 section-in-acceptance Renal Pharmacology

There was a mistake in Figure 2 as published. The image for the DFO group in Figure 2C was mistakenly replaced with the control group’s image, resulting in partial overlap between Figure 1C and Figure 2C. Additionally, to prevent misinterpretation of the ALI (25 μM) groups in Figures 1C and Figure 2C, we have used new images for the ALI group in Figure 2C. Finally, the housekeeping protein β-actin in Figure 2E was inadvertently duplicated from Figure 5C, and we have corrected this error. The corrected Figure 2 appears below.

ALI-induced cytotoxicity could be alleviated by iron chelator DFO. (A) Cell viability of HK-2 cells was detected using CCK-8 assay. (B) Intracellular Fe2+ levels in HK-2 cells treated by ALI and DFO. (C,D) Intracellular GSH content in HK-2 (X200). (E,F) The protein levels of 4-HNE were measured by Western blot. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. the control group; # p < 0.05, ## p < 0.01, ### p < 0.001, #### p < 0.0001 vs. the ALI group.

Bar graphs, fluorescence images, and Western blot results illustrating effects of different treatments: A) Cell viability comparison among control, DFO, ALI, and DFO+ALI groups. B) Fe2+ concentration levels. C) Fluorescence microscopy images for control, DFO, ALI, and DFO+ALI groups. D) GSH-MBB fluorescence intensity histogram. E) Western blot showing 4-HNE expression against β-actin. F) Bar graph of 4-HNE/β-actin ratio across groups. Statistical significance is indicated with asterisks and hashes.

The original article has been updated.

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Edited and reviewed by: Ying-Yong Zhao, Northwest University, China