In the published article, there was an error in Figures 3B,D, 5B,D,G,I as published. The previously published images were erroneously labeled in the source file. The corrected Figures 3B,D, 5B,D,G,I and their captions appear below.
Representative H&E staining of brain tissue from WT animals 24 h following TBI. (A) Cortex of Sham-WT animal. Original magnification X5. (B) Hippocampus of Sham-WT animal. The rectangle indicates the Ca1, Ca3, and stratus lacunosum moleculare areas used for enlargement. Original magnification X5. (C) Ca1 area of Sham-WT animal. Original magnification X40. (D) Ca3 area of Sham-WT animal. Original magnification X40. (E) Stratus lacunosum moleculare of Sham-WT animal. Original magnification X20. (F) Cortex of WT-TBI animal, the arrow indicates the impact point, hemorrhage and edema are markedly visible. Original magnification X5. (G) Hippocampus of WT-TBI animal. The rectangle indicates the Ca1 and Ca3 areas used for enlargement. Original magnification X5. (H) Ca1 area of WT-TBI animal, showing loss of normal architecture, presence of hemorrhage and edema, with shrank neurons. Original magnification X40. (I) Ca3 area of WT-TBI animal, showing diffused neuronal loss and presence of eosinophil neurons (arrows). Original magnification X40. (J) Stratus lacunosum moleculare of WT-TBI animal, showing hemorrhage and edema. Original magnification X20. (K) Cortex of WT-TBI + BAY 11-7082 animal, the arrow indicates the impact point, hemorrhage and edema are markedly visible. Original magnification X5. (L) Hippocampus of WT-TBI + BAY 11-7082 animal. The rectangle indicates the Ca1, Ca3, and stratus lacunosum moleculare areas used for enlargement. Original magnification X5. (M) Ca1 area of WT-TBI + BAY 11-7082 animal, showing a more preserved architecture, without hemorrhage or edema. Original magnification X40. (N) Ca3 area of WT-TBI + BAY 11-7082 animal, showing slight neuronal loss and presence of shrank and eosinophil neurons (arrows). Original magnification X40. (O) Stratus lacunosum moleculare of WT-TBI + BAY 11-7082 animal, showing a more preserved architecture. Original magnification X20.
Histological images of brain sections showing comparisons across Sham-WT, WT-TBI, and WT-TBI with BAY 11-7082 groups. Each row corresponds to a condition, with sections from cortex (A, F, K), hippocampus CA1 (B, G, L), CA3 (C, H, M), and stratum lacunosum moleculare (E, J, O). Differences, including tissue damage indicated by arrows, are visible between conditions.
Representative H&E staining of brain tissue from WT and NLRP3−/− mice 7 days following TBI. (A) Cortex of WT-TBI animal, the arrow indicates the impact point, hemorrhage and edema are still markedly visible. Original magnification X5. (B) Hippocampus of WT-TBI animal. The rectangle indicates the Ca1, Ca3, and stratus lacunosum moleculare areas used for enlargement. Original magnification X5. (C) Ca1 area of WT-TBI animal, showing partial restoration of normal architecture with shrank neurons. Original magnification X40. (D) Ca3 area of WT-TBI animal, showing neuronal loss and presence of eosinophil neurons (arrows). Original magnification X40. (E) Stratus lacunosum moleculare of WT-TBI animal, showing partially restored architecture. Original magnification X20. (F) Cortex of NLRP3−/−-TBI animal, the arrow indicates the impact point, hemorrhage and edema are markedly visible. Original magnification X5. (G) Hippocampus of NLRP3−/−-TBI animal. The rectangle indicates the Ca1, Ca3, and stratus lacunosum moleculare areas used for enlargement. Original magnification X5. (H) Ca1 area of NLRP3−/−-TBI animal, showing a preserved architecture, absence of hemorrhage and edema, with few shrank neurons. Original magnification X40. (I) Ca3 area of NLRP3−/−-TBI animal, showing neuronal loss and presence of eosinophil neurons (arrows). Original magnification X40. (J) Stratus lacunosum moleculare of NLRP3−/−-TBI animal, showing an almost normal architecture. Original magnification X20. (K) The graph represents the cumulative histological score evaluated at 7 days from each group of animals. §p < 0.05 vs. WT-TBI. Each bar represents the mean and SD of seven animals.
Histological images showing cortex and hippocampus regions in WT-TBI (A-E) and NLRP3-/- TBI (F-J) mice. Panels illustrate different areas and a bar graph (K) compares histological scores on the seventh day between WT-TBI and NLRP3-/- TBI groups.
Author Francesca Cosentino was incorrectly written as Cosentino Francesca.
The original article has been updated.
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Edited and reviewed by:Jacob Raber, Oregon Health and Science University, United States