AUTHOR=Kim Chae-Eun , Kim Kyong , Park Eun-Young , Oh Yoon Sin 

TITLE=Integrating clinical evidence with natural product therapies for elderly-onset type 2 diabetes 

JOURNAL=Frontiers in Pharmacology

VOLUME=Volume 16 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1658881

DOI=10.3389/fphar.2025.1658881

ISSN=1663-9812

ABSTRACT=Elderly-onset type 2 diabetes presents a distinct clinical profile, typically characterized by milder hyperglycemia and specific risks for complications. Age-related physiological changes and increased sensitivity to side effects often limit the use of conventional medications in this population. This review summarizes the epidemiology, clinical characteristics, and management challenges of diabetes in older adults and explores the therapeutic potential of natural bioactive compounds—including Enteromorpha prolifera, Ficus species, genipin, gingerol, mulberry, myricitrin, quercetin, resveratrol, and saffron. These findings not only provide mechanistic insights into the role of natural bioactive compounds in diabetes management but also highlight their clinical relevance, suggesting potential applications as adjunctive therapies for elderly individuals with limited pharmacological tolerance, and guiding future research toward evidence-based integration of such agents into clinical practice.