Front. Pharmacol. Frontiers in Pharmacology Front. Pharmacol. 1663-9812 Frontiers Media S.A. 1653830 10.3389/fphar.2025.1653830 Pharmacology Correction Correction: Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway Su et al. 10.3389/fphar.2025.1653830 Su Dan 1 † Li Qianmin 1 † Lai Xin 1 Song Yonggui 1 Li Huizhen 1 Ai Zhifu 1 Zhang Qi 1 Shao Wenxiang 1 Yang Ming 1 2 Zhu Genhua 1 * 1 Key Laboratory of Evaluation of Traditional Chinese Medicine Efficcacy (Prevention and Treatment of Brain Disease with Mental Disorders), Key Laboratory of Depression Animal Model Based on TCM Syndrome, Jiangxi Administration of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, China 2 Jiangxi Guxiang Jinyun Comprehensive Health Industry Co. Ltd., Nanchang, China

Edited and reviewed by: Karim Hosni, Institut National de Recherche et d'Analyse Physico-Chimique (INRAP), Tunisia

 *Correspondence: Genhua Zhu, zhugenhuajxzyy@163.com

These authors have contributed equally to this work

 14 10 2025 2025 16 1653830 25 06 2025 07 10 2025 Copyright © 2025 Su, Li, Lai, Song, Li, Ai, Zhang, Shao, Yang and Zhu. 2025 Su, Li, Lai, Song, Li, Ai, Zhang, Shao, Yang and Zhu

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 A Correction on Sargassum pallidum reduces inflammation to exert antidepressant effect by regulating intestinal microbiome and ERK1/2/P38 signaling pathway by Su D, Li Q, Lai X, Song Y, Li H, Ai Z, Zhang Q, Shao W, Yang M and Zhu G (2024). Front. Pharmacol. 15:1424834. doi: 10.3389/fphar.2024.1424834 sargassum pallidum network pharmacology inflammation antidepressant gut microbiota section-at-acceptance Ethnopharmacology

There was a mistake in Figure 2 as published. The cell morphology images of the “Control group”, “Model group”, and “PAR group” in Figure 2C were accidentally misused due to confusion in the naming of the experimental archive files, using some images from previous studies of the research group under the same experimental conditions. The immunofluorescence images of the “IL-1β Control group” and “IL-6 Control group” in Figure 2N were mistakenly pasted with the same control group image due to file classification errors during image export. The corrected Figure 2 appears below.

Protective effect of HHZ on LPS-induced inflammation in BV2 cells. (A,B) CCK-8 cell viability detection of HHZ extract and its active ingredient. (C) The effect of HHZ extract and LPS on the morphology of BV2 microglial cells (100X). (D–G) ELISA detection of TNF-α and IL-6 levels in BV2 cells. (H–J) After treatment with medicated serum, the expression levels of iNOS, NO, and IL-4 in BV2 cells. (K–N) Immunofluorescence analysis of TNF-α, IL-6, IL-1β. Values represent the mean ± SD. #p < 0.05, ##p < 0.01, ###p < 0.001, ####p < 0.0001 means significant difference compared with the control group; *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001 means significant difference compared with LPS group.

The image is a multi-panel scientific figure showing various charts and microscopic images. Panels A, B, D, E, F, G, H, I, and J contain bar graphs displaying cell viability and cytokine levels under different treatments. Panel C includes microscopic images of cell cultures under control and treated conditions. Panels K, L, M, and N feature fluorescence microscopy images showing staining for TNF-alpha, IL-6, and IL-1β, with associated graphs indicating fluorescence intensity. Each panel is labeled with control and treatment groups, highlighting experimental results.

The original article has been updated.

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