Front. Pharmacol.Frontiers in PharmacologyFront. Pharmacol.1663-9812Frontiers Media S.A.132032210.3389/fphar.2023.1320322PharmacologyCorrectionCorrigendum: Compound Dihuang Granule inhibits nigrostriatal pathway apoptosis in Parkinson’s disease by suppressing the JNK/AP-1 pathwayWang et al.10.3389/fphar.2023.1320322WangLi12YangYu-fang1ChenLong3HeZhu-qing1BiDian-yong1ZhangLei1XuYan-wu4*HeJian-cheng1*1Department of Diagnostics of Traditional Chinese Medicine, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China2Experiment Center, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese, Shanghai, China3Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China4Department of Biochemistry, School of Basic Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China
Edited and reviewed by:Alessandra Durazzo, Council for Agricultural Research and Economics, Italy
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A Corrigendum on Compound Dihuang Granule inhibits nigrostriatal pathway apoptosis in Parkinson’s disease by suppressing the JNK/AP-1 pathway by Wang L, Yang Y-f, Chen L, He Z-q, Bi D-y, Zhang L, Xu Y-w and He J-c (2021) Compound Dihuang Granule Inhibits Nigrostriatal Pathway Apoptosis in Parkinson’s Disease by Suppressing the JNK/AP-1 Pathway. Front. Pharmacol. 12:621359. doi: 10.3389/fphar.2021.621359Graphical Abstract
The graphical abstract of this study.
compound Dihuang GranuleParkinson’s diseaseapoptosistraditional Chinese medicineJNK/AP-1 pathwaynetwork pharmacologysection-at-acceptanceEthnopharmacology
In the published article, there was an error in Figure 6A, Figure 7A, Figure 8C and the Graphical Abstract as published. The striatum of Figure 6A and the CDG + SP600125 group of Figure 7A in the article were not the final version. This may have been caused by an initial error in the image layout editing process. The β-Actin in Figure 8C is misused. Figure 6A, Figure 7A and Figure 8C are part of the Graphical Abstract, so the Graphical Abstract also needs to be corrected. The corrected Figure 6, Figure 7, Figure 8, Graphical Abstract and their captions appear below.
6-OHDA-induced loss of DA neurons in the nigrostriatal pathway of the rat brain. (A) DAB staining of TH on midbrain sections in each group (Scale bar: 400 μm; Zoomed Scale bar: 100 μm). (B) Stereological counts of TH-positive cells of the SNpc at 6 weeks after 6-OHDA intoxication. (C) Average optical density of striatum in each group. (D) The expression level of TH proteins was detected with Western Blot in the striatum. (E) The expression level of TH protein in each group. β-Actin served as control. Statistical analysis was performed with One-Way ANOVA, n = 3. Significant differences were indicated by *p < 0.05, **p < 0.01, ***p < 0.001.
6-OHDA induced nigrostriatal pathway apoptosis of the PD rat brain. (A) TUNEL assay of apoptosis in each group. Representative confocal fluorescent images of the SNpc with TUNEL (green), TH (red), and DAPI (blue) (scale bar = 100 μm; Zoomed Scale bar; 20 μm). (B) Apoptosis index of the SNpc at 6 weeks after 6-OHDA intoxication. (C,D) The protein expression level of Bcl-2 and Bax were detected with Western Blot in the striatum. Statistical analysis was performed with One-Way ANOVA, n = 3. Significant differences were indicated by *p < 0.05, **p < 0.01, ***p < 0.001.
Expression of cleaved caspase-3 protein. (A) cleaved caspase-3 was detected by IF in each group. cleaved caspase-3 (green), TH (red) and DAPI (blue). (scale bar = 100 μm; Zoomed Scale bar: 20 μm). (B) The cleaved caspase-3 of TH-stained cells were calculated. (C,D) The expression level of cleaved caspase-3 protein was detected with Western Blot in the Striatum. β-Actin served as control. Statistical analysis was performed with One-Way ANOVA, Turkey’s multiple comparison test, post hoc, n = 3. Significant differences were indicated by *p < 0.05, **p < 0.01, ***p < 0.001.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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