Front. Pharmacol. Frontiers in Pharmacology Front. Pharmacol. 1663-9812 Frontiers Media S.A. 1122260 10.3389/fphar.2022.1122260 Pharmacology Correction Corrigendum: Intracerebroventricularly Injected Streptozotocin Exerts Subtle Effects on the Cognitive Performance of Long-Evans Rats Gáspár et al. 10.3389/fphar.2022.1122260 Gáspár Attila Hutka Barbara Ernyey Aliz Judit Tajti Brigitta Tekla Varga Bence Tamás Zádori Zoltán Sándor Gyertyán István * Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary

Edited and reviewed by: Arjan Blokland, Maastricht University, Netherlands

 *Correspondence: István Gyertyán, gyertyan.istvan@med.semmelweis-univ.hu

This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology

 05 01 2023 2022 13 1122260 12 12 2022 16 12 2022 Copyright © 2023 Gáspár, Hutka, Ernyey, Tajti, Varga, Zádori and Gyertyán. 2023 Gáspár, Hutka, Ernyey, Tajti, Varga, Zádori and Gyertyán

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 A Corrigendum on Intracerebroventricularly injected streptozotocin exerts subtle effects on the cognitive performance of long-evans rats by Gáspár A, Hutka B, Ernyey AJ, Tajti BT, Varga BT, Zádori ZS and Gyertyán I (2021) Front. Pharmacol. 12:662173. doi: 10.3389/fphar.2021.662173 Alzheimer disease model STZ icv. cognitive test battery learning impairment β-amyloid phospho-tau

In the published article, there was an error in Figure 8 as published. The results of a mistaken measurement were shown in Figures 8A, B. Consequently, the numerical values of the t-test comparing the phospho-tau/total tau ratios in the control and STZ treated groups in EXP1 and EXP2 are inadequate. The corrected Figure 8 and its corrected caption appear below:

The effect of icv. STZ or citrate buffer (control) treatment on the tissue protein levels of phospho-Tau (A,B) and β-amyloid (C,D) in EXP1 (A,C) and EXP2 (B,D) measured by Western blot. Means ± SEM values are shown. There was no significant difference between the groups in phospho-tau/tau ratio in EXP1 (unpaired t-test: t (14) = −0.19, ns) (A) whereas a trend for an increase in the STZ group can be seen in EXP2 (unpaired t-test: t (22) = −2.012, p = 0.06) (B) Also, there was no significant difference in β-amyloid level in EXP1 (unpaired t-test: t (13) = −1.13, ns) (C) while significantly elevated β-amyloid level was found in the STZ-treated group in EXP2 (unpaired t-test: t (20) = −2.45, p < 0.05 (D) *<0.05, #<0.10.

Furthermore, the name and catalogue number of the phospho-tau antibody in the Western Blot section was erroneous. As such, a correction has been made to “Methods and materials, Western Blot.” The sentence previously stated:

“Membranes were incubated with primary antibodies against PHF1 (sc515013, 1:1,000, Santa Cruz Biotechnology, Santa Cruz, CA, United States)…”

The corrected sentence appears below:

“Membranes were incubated with primary antibodies against PHF-13 (sc32275, 1:1,000, Santa Cruz Biotechnology, Santa Cruz, CA, United States)…”

The numerical values of the multivariate analysis of variance results were also inadequate. Therefore, a correction has been made to “Results, Multivariate analysis of variance.” The sentence previously stated:

“The difference between the control and STZ groups was significant in EXP2 (Wilks λ = 0.391, F(4,13) = 5.054; p = 0.011) whereas it was not significant in EXP1 (Wilks λ = 0.750, F(4,7) = 0.583; p = 0.685298344).”

The corrected sentence appears below:

“The difference between the control and STZ groups was significant in EXP2 (Wilks λ = 0.397, F(4,13) = 4,931; p = 0.012) whereas it was not significant in EXP1 (Wilks λ = 0.583, F(4,6) = 1.072; p = 0.446).”

The authors apologize for these errors and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. This is a provisional file, not the final typeset article

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