Front. Pharmacol. Frontiers in Pharmacology Front. Pharmacol. 1663-9812 Frontiers Media S.A. 1107928 10.3389/fphar.2022.1107928 Pharmacology Editorial Editorial: Needs and challenges associated with the therapeutic use of novel natural products in weight control and diabetes management Deliorman Orhan et al. 10.3389/fphar.2022.1107928 Deliorman Orhan Didem 1 Küpeli Akkol Esra 1 * Khan Haroon 2 1 Department of Pharmacognosy, Faculty of Pharmacy, Gazi University, Ankara, Turkey 2 Abdul Wali Khan University, Mardan, Pakistan

Edited and reviewed by: Filippo Drago, University of Catania, Italy

 *Correspondence: Esra Küpeli Akkol, esrak@gazi.edu.tr

This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

 16 01 2023 2022 13 1107928 25 11 2022 07 12 2022 Copyright © 2023 Deliorman Orhan, Küpeli Akkol and Khan. 2023 Deliorman Orhan, Küpeli Akkol and Khan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

 Editorial on the Research Topic Needs and challenges associated with the therapeutic use of novel natural products in weight control and diabetes management diabetes obesity molecular docking natural compound weight controlv

We are honored to publish the Research Topic “Needs and Challenges Associated with the Therapeutic Use of Novel Natural Products in Weight Control and Diabetes Management” as guest editors. This thematic title aims to evaluate in vitro and in vivo studies, structure-activity relationships, and new therapeutic targets on isolated natural compounds for use in diabetes management and weight control. Four review/research articles of the scientific publications sent per the thematic title were deemed suitable for publication.

Jiang et al. summarize the potential therapeutic effects of artemisinin and its derivatives in Type 2 Diabetes Mellitus (T2DM), its mechanism, and associated complications, and provided a scientific reference for further detailed studies on this Research Topic in the future. Bai et al. investigate the effects and possible mechanisms of gastrodin, the main component of a traditional Chinese herbal medicine called Gastrodia elata Blume, in the treatment of T2DM. The results of the study showed that gastrodin promotes the phosphorylation of GATA1 via the PI3K/AKT pathway, increases the transcriptional activity of GATA1, and subsequently increases the expression level of USP4, thereby reducing the ubiquitination and degradation of insulin receptors, and ultimately improving insulin resistance. Yang et al. discuss the types and functions of histone methylation and its role in T2DM treatment. In addition, the role of histone methyltransferases and histone demethylases in the progression of T2DM is reviewed and potential applications of histone methylation modification as a treatment target are evaluated. Pekacar and Deliorman Orhan evaluate the in vitro antidiabetic, antiobesity, antioxidant, and antihyperlipidemic effect potential of Pistacia atlantica Desf. leaves with an activity-guided fractionation study. The presence of trigalloylglucose, digalloylglucose, methyl gallate, methyl digallate, 2″-O-galloyl-quercetin-3-O-hexoside, and myricetin-3-O-hexoside was determined by LC-QTOF-MS analysis in the sub-fractions that had the highest inhibitory effect on α-amylase and α-glucosidase enzymes among the sub-fractions obtained from the ethyl acetate extract of the leaves. In these published scientific articles, natural compounds that can be used in the treatment of T2DM, their mechanism of action, the effects of epigenetic modifications in T2DM, and potential applications of histone methylation modification as a treatment target are examined. Thank you to all the authors who contributed to this Research Topic of Frontiers in Pharmacology and we hope that it will be useful to its readers.

Author contributions

All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication.

 Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

 Publisher’s note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.