AUTHOR=Pujol Manresa Anna , Buendía López Susana , Andión Maitane , Herrero Blanca , Lassaletta Álvaro , Ramirez Manuel , Ruano David , Hernández-Marqués Carmen , Varo Amalia , de Rojas Teresa , Cortés Hernández Marta , Verdú-Amorós Jaime , Martín Prado Silvia , Artigas Andrea , Redondo Esther , Ruiz Pato Julia , Herreros López Pilar , Sevilla Julián , Madero Luis , Moreno Lucas , Bautista Sirvent Francisco , Rubio-San-Simón Alba 

TITLE=Safety and outcome of children, adolescents and young adults participating in phase I/II clinical oncology trials: a 9-year center experience

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 12 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2024.1423484

DOI=10.3389/fped.2024.1423484

ISSN=2296-2360

ABSTRACT=95%CI: 9-15), higher in target-specific versus non-target-specific trials (14 vs 6 months; p=<0.001).Discussion: A significant and increasing number of patients have been included in early clinical trials, suggesting that both oncologists and families consider it valuable to be referred to specialized Units to access new therapies. Moreover, our data suggests that participation in early clinical trials, although not without potential toxicities, might have a positive impact on individual outcomes.