AUTHOR=Li Liming , Chen Sisi , Li Jianhong , Rong Guochou , Yang Juchao , Li Yunquan 

TITLE=Characterization of m6A-related lncRNA signature in neuroblastoma

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.927885

DOI=10.3389/fped.2022.927885

ISSN=2296-2360

ABSTRACT=N6-methyladenosine (m6A) is one of the most common modifications in mRNA, rRNA, tRNA, microRNA and long-chain non-coding RNA. The effect of m6A on the stability of RNA depends on m6A "Readers", "Writer" and "Erase". 
In this study, we identified a set of m6A-related genomic expression profiles in Neuroblastoma(NBL) based on Therapeutically Applicable Research To Generate Effective Treatments (TARGET：https://ocg.cancer.gov/programs/target). 
We identified two subgroups of Neuroblastoma (High-risk group and Low-risk group) by applying consensus clustering to m6A RNA methylation regulators. Compared with the Low-risk group, the High-risk group correlates with a poorer prognosis. Moreover, the present study also revealed that the high-risk group are significantly enriched in the tumor-related signaling pathways, including P53 signaling pathway, cell cycle and DNA repair. This finding indicates that these molecular prognostic markers may also be potentially valuable in early diagnosis, which provides a new research direction to study the molecular mechanisms underlying the development of NBL.
In colussion, the study constructed a new model of NBL prognosis based on m6a-associated lncRNAs. This model is helpful for stratification of prognosis and development of treatment strategies