AUTHOR=Buonsenso Danilo , Valentini Piero , Macchi Marina , Folino Francesco , Pensabene Carola , Patria Maria Francesca , Agostoni Carlo , Castaldi Silvana , Lecce Maurizio , Giannì Maria Lorella , Marchisio Paola , Milani Gregorio P. ,  The CHICO Study Group 

TITLE=Caregivers' Attitudes Toward COVID-19 Vaccination in Children and Adolescents With a History of SARS-CoV-2 Infection

JOURNAL=Frontiers in Pediatrics

VOLUME=Volume 10 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2022.867968

DOI=10.3389/fped.2022.867968

ISSN=2296-2360

ABSTRACT=Background
Limited data are available on the attitudes of caregivers towards COVID-19 vaccination in children and adolescents with a history of SARS-CoV-2 infection or Long Covid symptoms. The aim of this study was to investigate the vaccine hesitancy among caregivers of children and adolescents with a documented history of SARS-CoV-2 infection and to explore the possible associations between COVID-19 manifestations and the acceptance of the vaccine.
Methods
Caregivers of children or adolescents with a microbiologically confirmed diagnosis of SARS-CoV-2 infection evaluated in two University Hospitals were interviewed. 
Results
We were able to contact 132 caregivers and 9 declined to participate. (response rate 92%). 68 caregivers (56%) were in favor of COVID-19 vaccination for their child. In the multiple logistic regression, child’s age (OR 1.17, 95%CI 1.06-1.28) and hospitalization due to COVID-19 (OR 3.25, 95%CI 1.06-9.95) were positively associated with being in favor of COVID-19 vaccination. Conversely, the occurrence of child’s Long Covid was associated with a higher likelihood of being against the vaccination (OR 0.28, 95%CI 0.10-0.80).
Conclusions
This preliminary study shows that only about half of interviewed parents of children and adolescents with a previous SARS-CoV-2 infection are willing to vaccinate them to prevent a repeated COVID-19 infection. These findings might help healthcare workers to provide tailored information to caregivers of children with a previous SARS-CoV-2 infection.