AUTHOR=Campbell Anita J. , Tong Steven Y. C. , Davis Joshua S. , Munro Alasdair P. S. , Blyth Christopher C. , Bowen Asha C. 
  
TITLE=Infectious Diseases Clinician's Variation in the Management of Pediatric Staphylococcus aureus Bacteraemia and Equipoise for Clinical Trials
  
JOURNAL=Frontiers in Pediatrics
  
VOLUME=Volume 7 - 2019
  
YEAR=2019
  
URL=https://www.frontiersin.org/journals/pediatrics/articles/10.3389/fped.2019.00249
  
DOI=10.3389/fped.2019.00249
  
ISSN=2296-2360
  
ABSTRACT=Abstract

	Background

	Paediatric Staphylococcus aureus bacteraemia is now the leading cause of community-

	acquired blood-stream infection; however, our understanding of management practices by

	treating clinicians is limited.

	Methods

	The authors designed a web-based clinician survey with support from the Australian and New

	Zealand Paediatric Infectious Diseases group, of the Australasian Society of Infectious

	Diseases. Clinicians were presented with three paediatric cases of varying severity. Antibiotic

	choice, durations of intravenous and oral therapy and research priorities for paediatric SAB

	trials were gauged.

	Results and conclusion

	Large variation in antibiotic prescribing amongst clinicians for paediatric S. aureus

	bacteraemia is demonstrated and increased, corresponding with escalating case complexity

	and persisting MRSA bacteraemia. Most clinicians chose defining optimal duration of

        therapy for S. aureus bacteraemia as their top clinical trial priority. These findings highlight

	the importance of prioritising paediatric S. aureus bacteraemia clinical trials, to inform

	guidelines and best practice management.