AUTHOR=Dong Nana , Lin Tongtong 

TITLE=Innate immunity in chemotherapy-induced peripheral neuropathy: recent advances

JOURNAL=Frontiers in Pain Research

VOLUME=Volume 6 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/pain-research/articles/10.3389/fpain.2025.1642306

DOI=10.3389/fpain.2025.1642306

ISSN=2673-561X

ABSTRACT=Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect in patients undergoing chemotherapy. Many commonly used chemotherapeutic agents simultaneously induce neurotoxicity and modulate the immune system. Emerging evidence highlights a critical role of the innate immune system in the development of various neuropathic pain conditions. As a natural immune defense mechanism formed during phylogenetic evolution, innate immunity elicits a robust response during CIPN pathogenesis. This review summarizes the roles of the innate immune system—including the skin barrier, innate immune cells, and innate immune molecules—in the context of CIPN.