<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" "journalpublishing.dtd">
<article article-type="research-article" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xml:lang="EN">
<front>
<journal-meta>
<journal-id journal-id-type="publisher-id">Front. Oral Health</journal-id>
<journal-title>Frontiers in Oral Health</journal-title>
<abbrev-journal-title abbrev-type="pubmed">Front. Oral Health</abbrev-journal-title>
<issn pub-type="epub">2673-4842</issn>
<publisher>
<publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.3389/froh.2025.1511342</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Oral Health</subject>
<subj-group>
<subject>Original Research</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group>
<article-title>The Brons-Muli&#x00E9; analysis as a decision-making tool for preoperative surgical simulation in orthognatic surgery</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes"><name><surname>B&#x00F6;ttger</surname><given-names>Sebastian</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="corresp" rid="cor1">&#x002A;</xref><uri xlink:href="https://loop.frontiersin.org/people/2864534/overview"/><role content-type="https://credit.niso.org/contributor-roles/conceptualization/"/><role content-type="https://credit.niso.org/contributor-roles/data-curation/"/><role content-type="https://credit.niso.org/contributor-roles/investigation/"/><role content-type="https://credit.niso.org/contributor-roles/methodology/"/><role content-type="https://credit.niso.org/contributor-roles/project-administration/"/><role content-type="https://credit.niso.org/contributor-roles/validation/"/><role content-type="https://credit.niso.org/contributor-roles/writing-original-draft/"/></contrib>
<contrib contrib-type="author"><name><surname>Nowak</surname><given-names>Yannick</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><role content-type="https://credit.niso.org/contributor-roles/data-curation/"/><role content-type="https://credit.niso.org/contributor-roles/investigation/"/><role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/></contrib>
<contrib contrib-type="author"><name><surname>Windhorst</surname><given-names>Anita Cornelia</given-names></name>
<xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/2130789/overview" /><role content-type="https://credit.niso.org/contributor-roles/formal-analysis/"/><role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/></contrib>
<contrib contrib-type="author"><name><surname>Klaus</surname><given-names>Katharina</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref><role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/></contrib>
<contrib contrib-type="author"><name><surname>Ruf</surname><given-names>Sabine</given-names></name>
<xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/1220656/overview" /><role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/></contrib>
<contrib contrib-type="author"><name><surname>B&#x00E4;cker</surname><given-names>Christina</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><role content-type="https://credit.niso.org/contributor-roles/investigation/"/><role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/></contrib>
<contrib contrib-type="author"><name><surname>Schraml</surname><given-names>Eva May</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><role content-type="https://credit.niso.org/contributor-roles/investigation/"/><role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/></contrib>
<contrib contrib-type="author"><name><surname>Danevitch</surname><given-names>Nina</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><role content-type="https://credit.niso.org/contributor-roles/investigation/"/><role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/></contrib>
<contrib contrib-type="author"><name><surname>Muli&#x00E9;</surname><given-names>Rob</given-names></name>
<xref ref-type="aff" rid="aff4"><sup>4</sup></xref><role content-type="https://credit.niso.org/contributor-roles/methodology/"/><role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/></contrib>
<contrib contrib-type="author"><name><surname>Howaldt</surname><given-names>Hans-Peter</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref><role content-type="https://credit.niso.org/contributor-roles/conceptualization/"/><role content-type="https://credit.niso.org/contributor-roles/methodology/"/><role content-type="https://credit.niso.org/contributor-roles/supervision/"/><role content-type="https://credit.niso.org/contributor-roles/validation/"/><role content-type="https://credit.niso.org/contributor-roles/writing-review-editing/"/></contrib>
<contrib contrib-type="author"><name><surname>Attia</surname><given-names>Sameh</given-names></name>
<xref ref-type="aff" rid="aff1"><sup>1</sup></xref>
<xref ref-type="aff" rid="aff5"><sup>5</sup></xref><uri xlink:href="https://loop.frontiersin.org/people/1486762/overview" /></contrib>
</contrib-group>
<aff id="aff1"><label><sup>1</sup></label><institution>Department of Oral and Maxillofacial Surgery, Justus-Liebig-University Giessen, University Hospital Giessen</institution>, <addr-line>Giessen</addr-line>, <country>Germany</country></aff>
<aff id="aff2"><label><sup>2</sup></label><institution>Institute of Medical Informatics, Justus-Liebig-University Giessen</institution>, <addr-line>Giessen</addr-line>, <country>Germany</country></aff>
<aff id="aff3"><label><sup>3</sup></label><institution>Department of Orthodontics, Justus-Liebig-University Giessen</institution>, <addr-line>Giessen</addr-line>, <country>Germany</country></aff>
<aff id="aff4"><label><sup>4</sup></label><institution>Orthodontist, Orfeokliniek</institution>, <addr-line>Zoetermeer</addr-line>, <country>Holland</country></aff>
<aff id="aff5"><label><sup>5</sup></label><institution>Department of Periodontology, Oral Medicine and Oral Surgery, Charit&#x00E9;&#x2014;Universit&#x00E4;tsmedizin Berlin</institution>, <addr-line>Berlin</addr-line>, <country>Germany</country></aff>
<author-notes>
<fn fn-type="edited-by"><p><bold>Edited by:</bold> Riccardo Nucera, University of Messina, Italy</p></fn>
<fn fn-type="edited-by"><p><bold>Reviewed by:</bold> Sara Drago, University of Genoa, Italy</p>
<p>Matteo Brucoli, Universit&#x00E0; degli Studi del Piemonte Orientale, Italy</p></fn>
<corresp id="cor1"><label>&#x002A;</label><bold>Correspondence:</bold> Sebastian B&#x00F6;ttger <email>Sebastian.Boettger@uniklinikum-giessen.de</email></corresp>
</author-notes>
<pub-date pub-type="epub"><day>19</day><month>02</month><year>2025</year></pub-date>
<pub-date pub-type="collection"><year>2025</year></pub-date>
<volume>6</volume><elocation-id>1511342</elocation-id>
<history>
<date date-type="received"><day>14</day><month>10</month><year>2024</year></date>
<date date-type="accepted"><day>28</day><month>01</month><year>2025</year></date>
</history>
<permissions>
<copyright-statement>&#x00A9; 2025 B&#x00F6;ttger, Nowak, Windhorst, Klaus, Ruf, B&#x00E4;cker, Schraml, Danevitch, Muli&#x00E9;, Howaldt and Attia.</copyright-statement>
<copyright-year>2025</copyright-year><copyright-holder>B&#x00F6;ttger, Nowak, Windhorst, Klaus, Ruf, B&#x00E4;cker, Schraml, Danevitch, Muli&#x00E9;, Howaldt and Attia</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/">
<p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License (CC BY)</ext-link>. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</p></license>
</permissions>
<abstract><sec><title>Objectives</title>
<p>Sufficient preoperative planning represents an essential component for the success of orthognathic surgery. Using various analysis methods, dysmorphic areas can be reliably identified and addressed during the planning procedure.</p>
</sec><sec><title>Methods</title>
<p>Brons-Muli&#x00E9; analysis was used to examine profile photographs before and after orthognathic surgery. The attainment of normal values was interpreted as the achievement of facial harmony of the various facial proportions. By comparing the pre- and postoperative analysis, a control of the outcome quality of the orthognathic procedures was performed.</p>
</sec><sec><title>Results</title>
<p>In a total of 160 patients aged 13 to 61 years, the preoperative analysis could be compared with the postoperative Brons-Muli&#x00E9; analysis. Postoperative, facial harmony was found for the vertical dimension in 99 cases (62&#x0025;), for the upper lip dimension in 95 cases (59&#x0025;), for the lower lip dimension in 138 cases (86&#x0025;), and for the chin dimension in 118 cases (74&#x0025;). This corresponded to an improvement of 20&#x0025; in the vertical dimension, of 27&#x0025; in the area of the lower lip and of 6&#x0025; in the area of the chin. The upper lip area showed a slight deterioration of 7&#x0025;.</p>
</sec><sec><title>Conclusion</title>
<p>Despite preoperative planning of orthognathic surgery with Brons-Muli&#x00E9; analysis, postoperative results show an overall improvement but not perfection. Even by applying the method, it remains a challenge to achieve perfect facial harmony.</p>
</sec>
</abstract>
<kwd-group>
<kwd>Brons-Muli&#x00E9; analysis</kwd>
<kwd>orthognathic surgery</kwd>
<kwd>facial harmony</kwd>
<kwd>cephalometry</kwd>
<kwd>profile photography</kwd>
</kwd-group><counts>
<fig-count count="5"/>
<table-count count="4"/><equation-count count="0"/><ref-count count="32"/><page-count count="10"/><word-count count="0"/></counts><custom-meta-wrap><custom-meta><meta-name>section-at-acceptance</meta-name><meta-value>Oral and Maxillofacial Surgery</meta-value></custom-meta></custom-meta-wrap>
</article-meta>
</front>
<body><sec id="s1" sec-type="intro"><label>1</label><title>Introduction</title>
<p>Beauty and esthetics play an essential role in planning and implementation of orthognathic surgery. The objective is not only to transfer the bite into a neutral and stable occlusion, but also to create an overall esthetic and appealing appearance of the patient (<xref ref-type="bibr" rid="B1">1</xref>, <xref ref-type="bibr" rid="B2">2</xref>). But how is esthetics defined and how can it be measured? How and to what extent should the dental arches be displaced in order to achieve not only a proper occlusal result but also an equally favorable esthetic appearance of the patient&#x0027;s face? In the frontal view of the face, parallelism of the bi-pupillary line and the occlusal plane as well as symmetry of the facial halves certainly play an essential role (<xref ref-type="bibr" rid="B3">3</xref>&#x2013;<xref ref-type="bibr" rid="B5">5</xref>). Canut et al. describe that the &#x201C;beauty of the human face&#x201D;, however, depends primarily on a balance of the three prominent facial features nose, lips and chin (<xref ref-type="bibr" rid="B6">6</xref>). Reuther even refers to these features as the &#x201C;facial esthetic triad&#x201D; and thus gives them a decisive importance in facial analysis prior to orthognathic surgery (<xref ref-type="bibr" rid="B7">7</xref>). Brons-Muli&#x00E9;&#x0027;s soft tissue analysis, which can be performed on both cephalometric radiographs and profile photographs of the head, precisely analyzes these structures in the vertical and sagittal dimensions of the face (<xref ref-type="bibr" rid="B8">8</xref>). Facial harmony is achieved if the proportions of the anatomical structures to each other approximately correspond to the golden ratio (<xref ref-type="bibr" rid="B8">8</xref>). Since the nose as well as the lips and the chin can be strongly influenced by orthognathic surgery, the aim of the surgical procedure should be to bring these facial components into a condition of facial harmony as far as possible (<xref ref-type="bibr" rid="B8">8</xref>). Although in the end esthetics is always the result of a subjective assessment, achieving the proportions of facial harmony ultimately leads to a comprehensible, objective esthetics, based on the reproducible mathematical procedure of the Brons-Muli&#x00E9; analysis (<xref ref-type="bibr" rid="B8">8</xref>&#x2013;<xref ref-type="bibr" rid="B10">10</xref>). Thus, it can be applied as an auxiliary tool to plan a harmonious facial profile in orthognathic surgery, as described by Freihofer et al. and Mooren (<xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B10">10</xref>). Gu et al. were able to show that the lateral attractiveness of the face correlates well with frontal attractiveness. Thus, in case of a harmonious facial profile also good frontal esthetics can be expected (<xref ref-type="bibr" rid="B11">11</xref>). In addition, Brons-Muli&#x00E9; analysis can also be applied postoperatively to assess and to improve the quality of surgical results.</p>
<p>The question arises how often facial harmony can be achieved or at least be improved in the context of orthognathic surgery. Furthermore, the question arises if the Brons-Muli&#x00E9; analysis is suitable as a decision-making tool in preoperative surgical simulation.</p>
</sec>
<sec id="s2" sec-type="methods"><label>2</label><title>Materials and methods</title>
<sec id="s2a"><label>2.1</label><title>Planning procedure for orthognathic surgery</title>
<p>Preoperative simulation of surgery has been a standard procedure in orthognatic surgery for many years (<xref ref-type="bibr" rid="B12">12</xref>). This simulation can be performed either analogously using an articulator or digitally by computer programs (<xref ref-type="bibr" rid="B13">13</xref>). In the present study, all surgical simulations were performed using the 3D-OSS articulator according to Krenkel and Lixl (<xref ref-type="bibr" rid="B14">14</xref>). This device allows translational as well as rotational movements in all three dimensions on the basis of single-articulated plaster models. Thus, in particular esthetic aspects can be taken into account. Mock-up surgery was performed considering facial photographs, cephalometric examinations, and Brons-Muli&#x00E9; analysis of profile photographs of the face.</p>
</sec>
<sec id="s2b"><label>2.2</label><title>Evaluation of profile photographs</title>
<p>Profile photographs were taken with a digital SLR camera in front of a blue background with a distance of about 150&#x2005;cm. The digital images were printed out on an A4 page with a color printer in order to be able to carry out the soft tissue analysis according to Rob Muli&#x00E9; and Rijnko Brons using a pencil and a geo-triangle. In this way, the face is imaged approximately on a scale of 1:1 and can therefore also be compared well with the cephalometric images.</p>
</sec>
<sec id="s2c"><label>2.3</label><title>Brons-Muli&#x00E9; analysis</title>
<p>Brons-Muli&#x00E9; soft tissue analysis was performed for mock-up surgery approximately six weeks prior to surgery by the surgical team. For quality assurance, soft tissue analyses were repeated by the authors, using postoperative profile photographs, which were taken approximately six months after the operative intervention. As described by Brons (<xref ref-type="bibr" rid="B8">8</xref>), the nasal frontal line was drawn for this purpose and a vertical analysis line was drawn at an angle of 15 degrees to the caudal direction (<xref ref-type="fig" rid="F1">Figure&#x00A0;1</xref>). Concerning the vertical dimension, the nasofacial height (length of the nose between the nasion and the subnasal point) and the maxillofacial height (length of the upper lip) were determined. According to Rob Muli&#x00E9; and Rijnko Brons, an optimal value for the mandibulofacial height and a normal range with an upper and lower threshold were calculated from the ratio of these heights. In this context, the lower face was classified as a short face configuration if it was too short and as a long face configuration if it was too long. In the sagittal dimension, the angles between the vertical analysis line and the orientation of the upper lip (upper lip inclination: OLI), the lower lip (lower lip inclination: ULI) and the soft tissue pogonion (Mandibula inclination: MI) were determined. The normal range of these values with an upper and a lower threshold was determined depending on the nasal bridge inclination according to Rob Muli&#x00E9; and Rijnko Brons (<xref ref-type="bibr" rid="B8">8</xref>). A too retrogenous profile was described as a dorsal characteristic, a too progenic profile as a ventral characteristic. Facial harmony could be considered if the parameters of the vertical and sagittal dimensions were within the normal range. <xref ref-type="fig" rid="F2">Figure&#x00A0;2</xref> shows the Brons-Mulie analysis of a patient with a Class III malocclusion pre- and postoperatively.</p>
<fig id="F1" position="float"><label>Figure 1</label>
<caption><p>Brons-Muli&#x00E9; analysis in the vertical (left) and sagittal dimension (right). NFL, nasofrontal line; VAL, vertical analysis line; NasFH, nasofacial height; MaxFH, maxillofacial height; MandFH, mandibulofacial height; SF, shortface configuration limit; LF, longface configuration limit; NF, normalface&#x2014;optimal value for MandFH; NRI, nasal bridge inclination; OLI, upper lip inclination; ULI, lower lip inclination; MI, mandibula inclination; N, nasion; Sn, subnasale; St, stomion; Me, menton.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="froh-06-1511342-g001.tif"/>
</fig>
<fig id="F2" position="float"><label>Figure 2</label>
<caption><p>Brons-Muli&#x00E9;&#x0027;s analysis of a patient with class III malocclusion pre- and postoperatively. The yellow area shows the most suitable range for the vertical height. The triangles show the optimal areas for the inclination of the upper lip, the lower lip and the mandible.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="froh-06-1511342-g002.tif"/>
</fig>
</sec>
<sec id="s2d"><label>2.4</label><title>Statistical methods</title>
<p>Statistical analysis of this retrospective, expoloratory and descriptive study was performed using &#x201C;Microsoft Excel&#x201D; and the program &#x201C;Statistical Package for the Social Sciences&#x201D; (SPSS&#x00AE;) for Microsoft Windows in collaboration with the Research Group for Medical Statistics of the Justus Liebig University Giessen. All patients who underwent orthognathic surgery between February 2002 and February 2014 and for whom complete documentation was available at follow-up were included in the study. The preoperative and postoperative Brons-Muli&#x00E9; analyses of all patients were compared. Fisher&#x0027;s exact test was used to check whether the vertical (MandFH) and sagittal (OLI, ULI, MI) analysis values could be transferred to or kept within the normal range (&#x003D;success) or not (&#x003D;failure). In addition, logistic regression was performed to determine which parameters had the strongest influence on success or failure. All tests were performed with a significance level of <italic>p</italic>&#x2009;&#x003C;&#x2009;0.05. Power analysis was carried out with an alpha of 5&#x0025;, and an odds ratio of 2. In this way, a power of 0.62 to 0.86 can be achieved in dependence on the preoperative level of facial harmony (<xref ref-type="sec" rid="s11">Supplementary Table S3</xref>).</p>
</sec>
</sec>
<sec id="s3" sec-type="results"><label>3</label><title>Results</title>
<p>A total of 160 patients treated with orthognathic surgery between February 2002 and February 2014 were analyzed in this retrospective study. 99 patients (62&#x0025;) were female and 61 patients (38&#x0025;) were male. Age at the time of surgery ranged from 13 to 61 years with a median of 23 years. 64 patients (40&#x0025;) were treated for Class II malocclusion and 92 patients (57.5&#x0025;) for Class III malocclusion. The remaining patients underwent surgery due to a frontal open bite in Class I occlusion. 123 of 160 patients (76.9&#x0025;) underwent bimaxillary surgery, 24 patients (15&#x0025;) underwent bi-sagittal split osteotomy of the mandible, and 13 patients underwent Le Fort 1 osteotomy (8.1&#x0025;).</p>
<sec id="s3a"><label>3.1</label><title>Achievement of facial harmony</title>
<p>The examination for the presence of facial harmony was performed in the vertical and sagittal dimensions (OLI, ULI, MI). As expected, facial harmony was seen preoperatively in part of the cases only. Postoperatively, an overall improvement of the facial profiles was observed. However, isolated observation of the upper lip inclination (OLI) even showed a slight deterioration. <xref ref-type="table" rid="T1">Table&#x00A0;1</xref> and <xref ref-type="fig" rid="F3">Figure&#x00A0;3</xref> show the success rates in terms of achieving facial harmony as a result of orthognathic surgery.</p>
<table-wrap id="T1" position="float"><label>Table 1</label>
<caption><p>Prevalence of facial harmony before and after surgery in 160 patients.</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left">Facial Harmony</th>
<th valign="top" align="center" colspan="3">Pre-operative</th>
<th valign="top" align="center" colspan="3">Post-operative</th>
</tr>
<tr>
<th valign="top" align="center"/>
<th valign="top" align="center">Yes</th>
<th valign="top" align="center">No</th>
<th valign="top" align="center"/>
<th valign="top" align="center">Yes</th>
<th valign="top" align="center">No</th>
<th valign="top" align="center"/>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Vertical</td>
<td valign="top" align="center">67</td>
<td valign="top" align="center">93</td>
<td valign="top" align="center">42&#x0025;</td>
<td valign="top" align="center">99</td>
<td valign="top" align="center">61</td>
<td valign="top" align="center">62&#x0025;</td>
</tr>
<tr>
<td valign="top" align="left">OLI</td>
<td valign="top" align="center">106</td>
<td valign="top" align="center">54</td>
<td valign="top" align="center">66&#x0025;</td>
<td valign="top" align="center">95</td>
<td valign="top" align="center">65</td>
<td valign="top" align="center">59&#x0025;</td>
</tr>
<tr>
<td valign="top" align="left">ULI</td>
<td valign="top" align="center">95</td>
<td valign="top" align="center">65</td>
<td valign="top" align="center">59&#x0025;</td>
<td valign="top" align="center">138</td>
<td valign="top" align="center">22</td>
<td valign="top" align="center">86&#x0025;</td>
</tr>
<tr>
<td valign="top" align="left">MI</td>
<td valign="top" align="center">109</td>
<td valign="top" align="center">51</td>
<td valign="top" align="center">68&#x0025;</td>
<td valign="top" align="center">118</td>
<td valign="top" align="center">42</td>
<td valign="top" align="center">74&#x0025;</td>
</tr>
</tbody>
</table>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left">Facial harmony</th>
<th valign="top" align="center">Improvement</th>
<th valign="top" align="center">Aggravation</th>
<th valign="top" align="center">Odds ratio</th>
<th valign="top" align="center">CI (lower)</th>
<th valign="top" align="center">CI (upper)</th>
<th valign="top" align="center"><italic>p</italic></th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Vertical</td>
<td valign="top" align="center">44</td>
<td valign="top" align="center">12</td>
<td valign="top" align="center">5.05</td>
<td valign="top" align="center">2.31</td>
<td valign="top" align="center">11.77</td>
<td valign="top" align="center">&#x003C;0.01</td>
</tr>
<tr>
<td valign="top" align="left">OLI</td>
<td valign="top" align="center">21</td>
<td valign="top" align="center">32</td>
<td valign="top" align="center">3.60</td>
<td valign="top" align="center">1.73</td>
<td valign="top" align="center">7.66</td>
<td valign="top" align="center">&#x003C;0.01</td>
</tr>
<tr>
<td valign="top" align="left">ULI</td>
<td valign="top" align="center">47</td>
<td valign="top" align="center">4</td>
<td valign="top" align="center">8.59</td>
<td valign="top" align="center">2.63</td>
<td valign="top" align="center">36.90</td>
<td valign="top" align="center">&#x003C;0.01</td>
</tr>
<tr>
<td valign="top" align="left">MI</td>
<td valign="top" align="center">23</td>
<td valign="top" align="center">14</td>
<td valign="top" align="center">8.12</td>
<td valign="top" align="center">3.51</td>
<td valign="top" align="center">19.64</td>
<td valign="top" align="center">&#x003C;0.01</td>
</tr>
</tbody>
</table>
</table-wrap>
<fig id="F3" position="float"><label>Figure 3</label>
<caption><p>Improvement of facial harmony before and after orthognathic surgery. Vertical, vertical dimension; OLI, upper lip inclination; ULI, lower lip inclination; MI, mandibula inclination.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="froh-06-1511342-g003.tif"/>
</fig>
</sec>
<sec id="s3b"><label>3.2</label><title>Factors influencing success</title>
<p><xref ref-type="fig" rid="F3">Figure&#x00A0;3</xref> shows that although orthognathic surgery was able to enhance facial harmony, the overall success rate was only moderately improved. Therefore, the question arises which patients or constellations may not have been adequately corrected. <xref ref-type="table" rid="T2">Table&#x00A0;2</xref> shows the distribution of success and failure depending on pre-operative classification according to Angle. In this context, the Fisher&#x0027;s exact test showed a significant result for the vertical dimension and the mandibula inclination (<xref ref-type="table" rid="T2">Table&#x00A0;2</xref>). Thus, post-operatively, almost half of the patients with class III showed missing facial harmony in the vertical dimension and almost half of the patients with class II showed missing facial harmony with respect to the Mandibula inclination.</p>
<table-wrap id="T2" position="float"><label>Table 2</label>
<caption><p>Facial harmony depending on angle class.</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left"/>
<th valign="top" align="left">Angle class</th>
<th valign="top" align="center">Yes</th>
<th valign="top" align="center">(&#x0025;)</th>
<th valign="top" align="center">No</th>
<th valign="top" align="center">(&#x0025;)</th>
<th valign="top" align="center">Total</th>
<th valign="top" align="center"><italic>p</italic>&#x002A;</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">Vertical</td>
<td valign="top" align="left">Class I</td>
<td valign="top" align="center">3</td>
<td valign="top" align="center">75.0&#x0025;</td>
<td valign="top" align="center">1</td>
<td valign="top" align="center">25.0&#x0025;</td>
<td valign="top" align="center">4</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Class II</td>
<td valign="top" align="center">47</td>
<td valign="top" align="center">73.4&#x0025;</td>
<td valign="top" align="center">17</td>
<td valign="top" align="center">26.6&#x0025;</td>
<td valign="top" align="center">64</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Class III</td>
<td valign="top" align="center">49</td>
<td valign="top" align="center">53.3&#x0025;</td>
<td valign="top" align="center">43</td>
<td valign="top" align="center">46.7&#x0025;</td>
<td valign="top" align="center">92</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Total</td>
<td valign="top" align="center">99</td>
<td valign="top" align="center">61.9&#x0025;</td>
<td valign="top" align="center">61</td>
<td valign="top" align="center">38.1&#x0025;</td>
<td valign="top" align="center">160</td>
<td valign="top" align="center"><italic>p</italic>&#x2009;&#x003D;&#x2009;0.025&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left">OLI</td>
<td valign="top" align="left">Class I</td>
<td valign="top" align="center">3</td>
<td valign="top" align="center">75.0&#x0025;</td>
<td valign="top" align="center">1</td>
<td valign="top" align="center">25.0&#x0025;</td>
<td valign="top" align="center">4</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Class II</td>
<td valign="top" align="center">40</td>
<td valign="top" align="center">62.5&#x0025;</td>
<td valign="top" align="center">24</td>
<td valign="top" align="center">37.5&#x0025;</td>
<td valign="top" align="center">64</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Class III</td>
<td valign="top" align="center">52</td>
<td valign="top" align="center">56.5&#x0025;</td>
<td valign="top" align="center">40</td>
<td valign="top" align="center">43.5&#x0025;</td>
<td valign="top" align="center">92</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Total</td>
<td valign="top" align="center">95</td>
<td valign="top" align="center">59.4&#x0025;</td>
<td valign="top" align="center">65</td>
<td valign="top" align="center">40.6&#x0025;</td>
<td valign="top" align="center">160</td>
<td valign="top" align="center"><italic>p</italic>&#x2009;&#x003D;&#x2009;0.623</td>
</tr>
<tr>
<td valign="top" align="left">ULI</td>
<td valign="top" align="left">Class I</td>
<td valign="top" align="center">4</td>
<td valign="top" align="center">100.0&#x0025;</td>
<td valign="top" align="center">0</td>
<td valign="top" align="center">0.0&#x0025;</td>
<td valign="top" align="center">4</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Class II</td>
<td valign="top" align="center">57</td>
<td valign="top" align="center">89.1&#x0025;</td>
<td valign="top" align="center">7</td>
<td valign="top" align="center">10.9&#x0025;</td>
<td valign="top" align="center">64</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Class III</td>
<td valign="top" align="center">77</td>
<td valign="top" align="center">83.7&#x0025;</td>
<td valign="top" align="center">15</td>
<td valign="top" align="center">16.3&#x0025;</td>
<td valign="top" align="center">92</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Total</td>
<td valign="top" align="center">138</td>
<td valign="top" align="center">86.2&#x0025;</td>
<td valign="top" align="center">22</td>
<td valign="top" align="center">13.8&#x0025;</td>
<td valign="top" align="center">160</td>
<td valign="top" align="center"><italic>p</italic>&#x2009;&#x003D;&#x2009;0.716</td>
</tr>
<tr>
<td valign="top" align="left">MI</td>
<td valign="top" align="left">Class I</td>
<td valign="top" align="center">4</td>
<td valign="top" align="center">100.0&#x0025;</td>
<td valign="top" align="center">0</td>
<td valign="top" align="center">0.0&#x0025;</td>
<td valign="top" align="center">4</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Class II</td>
<td valign="top" align="center">34</td>
<td valign="top" align="center">53.1&#x0025;</td>
<td valign="top" align="center">30</td>
<td valign="top" align="center">46.9&#x0025;</td>
<td valign="top" align="center">64</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Class III</td>
<td valign="top" align="center">80</td>
<td valign="top" align="center">86.9&#x0025;</td>
<td valign="top" align="center">12</td>
<td valign="top" align="center">13.1&#x0025;</td>
<td valign="top" align="center">92</td>
<td valign="top" align="center"/>
</tr>
<tr>
<td valign="top" align="left"/>
<td valign="top" align="left">Total</td>
<td valign="top" align="center">118</td>
<td valign="top" align="center">73.8&#x0025;</td>
<td valign="top" align="center">42</td>
<td valign="top" align="center">26.2&#x0025;</td>
<td valign="top" align="center">160</td>
<td valign="top" align="center"><italic>p</italic>&#x2009;&#x003C;&#x2009;0.001&#x002A;</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table-fn1"><p>Fisher&#x0027;s exact test showed a significant result for the vertical dimension and the Mandibula inclination (&#x002A;).</p></fn>
</table-wrap-foot>
</table-wrap>
<p>In order to investigate which factors mostly influence success or failure, a logistic regression analysis was performed in which the variables Angle Class, vertical height, upper lip inclination, lower lip inclination, Mandibula inclination, gender, surgery type (Le Fort 1/BSSO/Bimax) and age were included. The best model to explain success was selected using the Akaike criterion (<xref ref-type="table" rid="T3">Table&#x00A0;3</xref>).</p>
<table-wrap id="T3" position="float"><label>Table 3</label>
<caption><p>Logistic regression analysis using the variables angle class, vertical height (vertical), upper lip inclincation (OLI), lower lip inclination (ULI), mandibula inclination (MI), gender, surgery type (le fort 1/BSSO/Bimax.) and age. Akaike criterion was used to select the variables for the best model to explain postoperative success in the four dimensions (vertical dimension, upper lip inclination, lower lip inclination and mandibula inclination).</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="left"/>
<col align="center"/>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="left"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left">Success</th>
<th valign="top" align="center">Df</th>
<th valign="top" align="center">Deviance</th>
<th valign="top" align="center">Resid. Df</th>
<th valign="top" align="center">Resid. Dev</th>
<th valign="top" align="center">Pr(&#x003E;Chi)</th>
<th valign="top" align="center"/>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left" colspan="7">Vertical Dimension</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. Vertical</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">24.9</td>
<td valign="top" align="center">157</td>
<td valign="top" align="center">187.79</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">&#x002A;&#x002A;&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. OLI</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">6.53</td>
<td valign="top" align="center">155</td>
<td valign="top" align="center">181.27</td>
<td valign="top" align="center">0.038</td>
<td valign="top" align="center">&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. MI</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">7.26</td>
<td valign="top" align="center">153</td>
<td valign="top" align="center">174.01</td>
<td valign="top" align="center">0.027</td>
<td valign="top" align="center">&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left" colspan="7">Mandibula-Inclination</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. MI</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">31.00</td>
<td valign="top" align="center">157</td>
<td valign="top" align="center">153.21</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">&#x002A;&#x002A;&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left">Gender</td>
<td valign="top" align="center">1</td>
<td valign="top" align="center">1.86</td>
<td valign="top" align="center">156</td>
<td valign="top" align="center">151.36</td>
<td valign="top" align="center">0.173</td>
<td valign="top" align="left"/>
</tr>
<tr>
<td valign="top" align="left">Surgery type</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">9.23</td>
<td valign="top" align="center">154</td>
<td valign="top" align="center">142.13</td>
<td valign="top" align="center">0.01</td>
<td valign="top" align="center">&#x002A;&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left" colspan="7">Upper Lip-Inclination</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. OLI</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">14.19</td>
<td valign="top" align="center">157</td>
<td valign="top" align="center">201.96</td>
<td valign="top" align="center">0.001</td>
<td valign="top" align="center">&#x002A;&#x002A;&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. MI</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">6.94</td>
<td valign="top" align="center">155</td>
<td valign="top" align="center">195.02</td>
<td valign="top" align="center">0.031</td>
<td valign="top" align="center">&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. ULI</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">11.85</td>
<td valign="top" align="center">153</td>
<td valign="top" align="center">183.17</td>
<td valign="top" align="center">0.003</td>
<td valign="top" align="center">&#x002A;&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left" colspan="7">Lower Lip-Inclination</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. ULI</td>
<td valign="top" align="center">2</td>
<td valign="top" align="center">18.56</td>
<td valign="top" align="center">157</td>
<td valign="top" align="center">109.57</td>
<td valign="top" align="center">&#x003C;0.001</td>
<td valign="top" align="center">&#x002A;&#x002A;&#x002A;</td>
</tr>
<tr>
<td valign="top" align="left">Gender</td>
<td valign="top" align="center">1</td>
<td valign="top" align="center">3.29</td>
<td valign="top" align="center">156</td>
<td valign="top" align="center">106.28</td>
<td valign="top" align="center">0.07</td>
<td valign="top" align="center">.</td>
</tr>
<tr>
<td valign="top" align="left">Age</td>
<td valign="top" align="center">1</td>
<td valign="top" align="center">3.43</td>
<td valign="top" align="center">155</td>
<td valign="top" align="center">102.85</td>
<td valign="top" align="center">0.064</td>
<td valign="top" align="center">.</td>
</tr>
</tbody>
</table>
</table-wrap>
<p>In particular, the preoperative mandibulofacial height was shown to determine success in the vertical direction. Thus, a preoperative long face constellation was associated with a high postoperative failure rate in the vertical dimension (<xref ref-type="table" rid="T3">Tables&#x00A0;3</xref>, <xref ref-type="table" rid="T4">Table&#x00A0;4</xref>). Preoperative decreased and increased Mandibula inclination was shown to be most predictive for success of the Mandibula inclination. <xref ref-type="table" rid="T4">Table&#x00A0;4</xref> shows that only few of the patients with these constellations show facial harmony of the Mandibula inclination postoperatively. With regard to the lower lip inclination, increased or decreased inclination of the lower lip itself were the main factors determining success.</p>
<table-wrap id="T4" position="float"><label>Table 4</label>
<caption><p>In addition to <xref ref-type="table" rid="T3">Table&#x00A0;3</xref>, the logistic regression analysis examined the individual characteristics of the variables with regard to their influence on success.</p></caption>
<table frame="hsides" rules="groups">
<colgroup>
<col align="left"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
<col align="center"/>
</colgroup>
<thead>
<tr>
<th valign="top" align="left">Success vertical</th>
<th valign="top" align="center">Estimate</th>
<th valign="top" align="center">Odds Ratio</th>
<th valign="top" align="center">CI (lower)</th>
<th valign="top" align="center">CI (upper)</th>
<th valign="top" align="center">Std. Error</th>
<th valign="top" align="center">z value</th>
<th valign="top" align="center">Pr(&#x003E;&#x007C;z&#x007C;)</th>
</tr>
</thead>
<tbody>
<tr>
<td valign="top" align="left">(Intercept)</td>
<td valign="top" align="center">2.06</td>
<td valign="top" align="center">7.82</td>
<td valign="top" align="center">3.76</td>
<td valign="top" align="center">18.82</td>
<td valign="top" align="center">0.41</td>
<td valign="top" align="center">4.97</td>
<td valign="top" align="center">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. vertical: SF</td>
<td valign="top" align="center">&#x2212;0.59</td>
<td valign="top" align="center">0.56</td>
<td valign="top" align="center">0.18</td>
<td valign="top" align="center">1.71</td>
<td valign="top" align="center">0.56</td>
<td valign="top" align="center">&#x2212;1.04</td>
<td valign="top" align="center">0.298</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. vertical: LF</td>
<td valign="top" align="center">&#x2212;2.17</td>
<td valign="top" align="center">0.11</td>
<td valign="top" align="center">0.05</td>
<td valign="top" align="center">0.27</td>
<td valign="top" align="center">0.45</td>
<td valign="top" align="center">&#x2212;4.79</td>
<td valign="top" align="center">&#x003C;0.001</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. OLI: H</td>
<td valign="top" align="center">&#x2212;1.01</td>
<td valign="top" align="center">0.36</td>
<td valign="top" align="center">0.14</td>
<td valign="top" align="center">0.9</td>
<td valign="top" align="center">0.47</td>
<td valign="top" align="center">&#x2212;2.15</td>
<td valign="top" align="center">0.031</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. OLI: L</td>
<td valign="top" align="center">0.98</td>
<td valign="top" align="center">2.67</td>
<td valign="top" align="center">0.81</td>
<td valign="top" align="center">10.73</td>
<td valign="top" align="center">0.65</td>
<td valign="top" align="center">1.51</td>
<td valign="top" align="center">0.13</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. MI: H</td>
<td valign="top" align="center">&#x2212;0.06</td>
<td valign="top" align="center">0.94</td>
<td valign="top" align="center">0.26</td>
<td valign="top" align="center">3.42</td>
<td valign="top" align="center">0.64</td>
<td valign="top" align="center">&#x2212;0.09</td>
<td valign="top" align="center">0.929</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. MI: L</td>
<td valign="top" align="center">&#x2212;1.33</td>
<td valign="top" align="center">0.26</td>
<td valign="top" align="center">0.09</td>
<td valign="top" align="center">0.7</td>
<td valign="top" align="center">0.51</td>
<td valign="top" align="center">&#x2212;2.61</td>
<td valign="top" align="center">0.009</td>
</tr>
<tr>
<th valign="top" align="left">Success MI</th>
<th valign="top" align="center">Estimate</th>
<th valign="top" align="center">Odds Ratio</th>
<th valign="top" align="center">CI (lower)</th>
<th valign="top" align="center">CI (upper)</th>
<th valign="top" align="center">Sth. Error</th>
<th valign="top" align="center">z value</th>
<th valign="top" align="center">Pr(&#x003E;&#x007C;z&#x007C;)</th>
</tr>
<tr>
<td valign="top" align="left">(Intercept)</td>
<td valign="top" align="center">18.47</td>
<td valign="top" align="center"/>
<td valign="top" align="center">0.00</td>
<td valign="top" align="center"/>
<td valign="top" align="center">1048.17</td>
<td valign="top" align="center">0.02</td>
<td valign="top" align="center">0.986</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. MI: H</td>
<td valign="top" align="center">&#x2212;1.75</td>
<td valign="top" align="center">0.17</td>
<td valign="top" align="center">0.05</td>
<td valign="top" align="center">0.60</td>
<td valign="top" align="center">0.63</td>
<td valign="top" align="center">&#x2212;2.77</td>
<td valign="top" align="center">0.006</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. MI: L</td>
<td valign="top" align="center">&#x2212;2.19</td>
<td valign="top" align="center">0.11</td>
<td valign="top" align="center">0.04</td>
<td valign="top" align="center">0.28</td>
<td valign="top" align="center">0.49</td>
<td valign="top" align="center">&#x2212;4.47</td>
<td valign="top" align="center">&#x003C;0,001</td>
</tr>
<tr>
<td valign="top" align="left">Gender: female</td>
<td valign="top" align="center">&#x2212;0.78</td>
<td valign="top" align="center">0.46</td>
<td valign="top" align="center">0.18</td>
<td valign="top" align="center">1.13</td>
<td valign="top" align="center">0.47</td>
<td valign="top" align="center">&#x2212;1.67</td>
<td valign="top" align="center">0.095</td>
</tr>
<tr>
<td valign="top" align="left">BSSO</td>
<td valign="top" align="center">&#x2212;15.25</td>
<td valign="top" align="center">0.00</td>
<td valign="top" align="center">0.00</td>
<td valign="top" align="center"/>
<td valign="top" align="center">1048.17</td>
<td valign="top" align="center">&#x2212;0.01</td>
<td valign="top" align="center">0.988</td>
</tr>
<tr>
<td valign="top" align="left">Bimax.</td>
<td valign="top" align="center">&#x2212;16.34</td>
<td valign="top" align="center">0.00</td>
<td valign="top" align="center"/>
<td valign="top" align="center"/>
<td valign="top" align="center">1048.17</td>
<td valign="top" align="center">&#x2212;0.02</td>
<td valign="top" align="center">0.988</td>
</tr>
<tr>
<th valign="top" align="left">Success OLI</th>
<th valign="top" align="center">Estimate</th>
<th valign="top" align="center">Odds Ratio</th>
<th valign="top" align="center">CI (lower)</th>
<th valign="top" align="center">CI (upper)</th>
<th valign="top" align="center">Sth. Error</th>
<th valign="top" align="center">z value</th>
<th valign="top" align="center">Pr(&#x003E;&#x007C;z&#x007C;)</th>
</tr>
<tr>
<td valign="top" align="left">(Intercept)</td>
<td valign="top" align="center">0.95</td>
<td valign="top" align="center">2.57</td>
<td valign="top" align="center">1.53</td>
<td valign="top" align="center">4.49</td>
<td valign="top" align="center">0.27</td>
<td valign="top" align="center">3.46</td>
<td valign="top" align="center">0.001</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. OLI: H</td>
<td valign="top" align="center">&#x2212;1.09</td>
<td valign="top" align="center">0.34</td>
<td valign="top" align="center">0.12</td>
<td valign="top" align="center">0.88</td>
<td valign="top" align="center">0.5</td>
<td valign="top" align="center">&#x2212;2.19</td>
<td valign="top" align="center">0.029</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. OLI: L</td>
<td valign="top" align="center">&#x2212;1.15</td>
<td valign="top" align="center">0.32</td>
<td valign="top" align="center">0.10</td>
<td valign="top" align="center">0.95</td>
<td valign="top" align="center">0.57</td>
<td valign="top" align="center">&#x2212;2.03</td>
<td valign="top" align="center">0.042</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. MI: H</td>
<td valign="top" align="center">2.08</td>
<td valign="top" align="center">7.98</td>
<td valign="top" align="center">2.02</td>
<td valign="top" align="center">42.03</td>
<td valign="top" align="center">0.76</td>
<td valign="top" align="center">2.75</td>
<td valign="top" align="center">0.006</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. MI: L</td>
<td valign="top" align="center">0.70</td>
<td valign="top" align="center">2.01</td>
<td valign="top" align="center">0.80</td>
<td valign="top" align="center">5.44</td>
<td valign="top" align="center">0.48</td>
<td valign="top" align="center">1.44</td>
<td valign="top" align="center">0.15</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. ULI: H</td>
<td valign="top" align="center">&#x2212;0.96</td>
<td valign="top" align="center">0.38</td>
<td valign="top" align="center">0.16</td>
<td valign="top" align="center">0.93</td>
<td valign="top" align="center">0.45</td>
<td valign="top" align="center">&#x2212;2.12</td>
<td valign="top" align="center">0.034</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. ULI: L</td>
<td valign="top" align="center">&#x2212;1.98</td>
<td valign="top" align="center">0.14</td>
<td valign="top" align="center">0.03</td>
<td valign="top" align="center">0.5</td>
<td valign="top" align="center">0.69</td>
<td valign="top" align="center">&#x2212;2.87</td>
<td valign="top" align="center">0.004</td>
</tr>
<tr>
<th valign="top" align="left">Success ULI</th>
<th valign="top" align="center">Estimate</th>
<th valign="top" align="center">Odds Ratio</th>
<th valign="top" align="center">CI (lower)</th>
<th valign="top" align="center">CI (upper)</th>
<th valign="top" align="center">Sth. Error</th>
<th valign="top" align="center">z value</th>
<th valign="top" align="center">Pr(&#x003E;&#x007C;z&#x007C;)</th>
</tr>
<tr>
<td valign="top" align="left">(Intercept)</td>
<td valign="top" align="center">1.27</td>
<td valign="top" align="center">3.56</td>
<td valign="top" align="center">0.53</td>
<td valign="top" align="center">23.21</td>
<td valign="top" align="center">0.95</td>
<td valign="top" align="center">1.34</td>
<td valign="top" align="center">0.179</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. ULI: H</td>
<td valign="top" align="center">&#x2212;2.24</td>
<td valign="top" align="center">0.11</td>
<td valign="top" align="center">0.03</td>
<td valign="top" align="center">0.34</td>
<td valign="top" align="center">0.63</td>
<td valign="top" align="center">&#x2212;3.54</td>
<td valign="top" align="center">&#x003C;0,001</td>
</tr>
<tr>
<td valign="top" align="left">Pre-op. ULI: L</td>
<td valign="top" align="center">&#x2212;2.74</td>
<td valign="top" align="center">0.06</td>
<td valign="top" align="center">0.01</td>
<td valign="top" align="center">0.3</td>
<td valign="top" align="center">0.8</td>
<td valign="top" align="center">&#x2212;3.42</td>
<td valign="top" align="center">0.001</td>
</tr>
<tr>
<td valign="top" align="left">Gender: female</td>
<td valign="top" align="center">0.98</td>
<td valign="top" align="center">2.67</td>
<td valign="top" align="center">0.99</td>
<td valign="top" align="center">7.59</td>
<td valign="top" align="center">0.51</td>
<td valign="top" align="center">1.91</td>
<td valign="top" align="center">0.056</td>
</tr>
<tr>
<td valign="top" align="left">Age</td>
<td valign="top" align="center">0.06</td>
<td valign="top" align="center">1.06</td>
<td valign="top" align="center">1.00</td>
<td valign="top" align="center">1.15</td>
<td valign="top" align="center">0.04</td>
<td valign="top" align="center">1.69</td>
<td valign="top" align="center">0.092</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="table-fn2"><p>SF, short face; LF, Long face; H, too high; L, too low; BSSO, bisagittal split osteotomy; Bimax, bimaxillary sugery.</p></fn>
</table-wrap-foot>
</table-wrap>
</sec>
</sec>
<sec id="s4" sec-type="discussion"><label>4</label><title>Discussion</title>
<p>A careful planning procedure is essential to ensure favorable surgical outcome in orthognatic surgery (<xref ref-type="bibr" rid="B12">12</xref>). It should not only lead to a stable occlusion, but also to a functionally and esthetically acceptable overall result (<xref ref-type="bibr" rid="B2">2</xref>, <xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B10">10</xref>, <xref ref-type="bibr" rid="B12">12</xref>, <xref ref-type="bibr" rid="B15">15</xref>). Steenen reported that correction of a disharmonious face is at least as important to patients as oral function recovery (<xref ref-type="bibr" rid="B16">16</xref>). Brucoli et al. pointed out that the creation of harmonious facial aesthetics can have a positive effect on patients&#x0027; compliance and psychological status (<xref ref-type="bibr" rid="B17">17</xref>), and Wang et al. also reported positive effects of orthognathic surgery on patients&#x0027; psychological well-being (<xref ref-type="bibr" rid="B18">18</xref>). This further emphasizes the enormous importance of facial esthetics in orthognathic surgery.</p>
<p>The esthetic appearance of the face depends on symmetry, averageness and the proportions of different parts of the face to each other (<xref ref-type="bibr" rid="B5">5</xref>, <xref ref-type="bibr" rid="B9">9</xref>). Furthermore, it is evident that lateral attractiveness of the face correlates well with frontal attractiveness (<xref ref-type="bibr" rid="B11">11</xref>). Since orthognathic surgery can have a significant impact on facial profile in both, the vertical and sagittal dimension of the face, Freihofer and Mooren recommended defining an aimed-at profile line prior to orthognathic surgery, to which the postoperative result on the patient should approximate as closely as possible (<xref ref-type="bibr" rid="B9">9</xref>). But they were also able to show that free artistic drawing of such an aimed-at profile leads to strong variations even among experts and that the result therefore depends highly on individual preferences (<xref ref-type="bibr" rid="B9">9</xref>). Thus, Freihofer and Mooren recommend the use of the Brons-Muli&#x00E9; analysis to determine an aimed-at profile as objectively as possible in order to achieve reproducible and attractive postoperative soft tissue esthetics (<xref ref-type="bibr" rid="B9">9</xref>, <xref ref-type="bibr" rid="B10">10</xref>).</p>
<p>With the concept of facial harmony, the Brons-Mulie analysis offers a simple tool for assessing facial esthetics, which can be used in addition to standard cephalometric analysis in the planning procedure prior to orthognathic surgery (<xref ref-type="bibr" rid="B8">8</xref>). In the vertical dimension the analysis offers a valuable supplement which allows a direct assessment of the vertical facial height. In the sagittal dimension the tool provides an evaluation of the soft tissue pogonion which in contrast to cephalometric analysis is independent of the angulation of the anterior cranial base (<xref ref-type="bibr" rid="B8">8</xref>). Further, the tool complements standard cephalometric analysis with an assessment of the lip position.</p>
<p>In the present study, a preoperative Brons-Muli&#x00E9; analysis was carried out preoperatively for all 160 patients in order to achieve an approximately harmonious profile line by performing orthognathic surgery. The outcome was assessed with a second postoperative Brons-Muli&#x00E9; analysis of the face. Data of this work show that despite preoperative application of the Brons-Mulie analysis as a decision-making tool, postoperative facial harmony in the vertical and sagittal dimension is not easy to achieve in every case. <xref ref-type="table" rid="T1">Table&#x00A0;1</xref> and <xref ref-type="fig" rid="F1">Figure&#x00A0;1</xref> show that only the vertical dimension and the lower lip inclination could be markedly improved by 20&#x0025; and 27&#x0025;, respectively. In contrast, the Mandibula inclination could only be improved by 6&#x0025; and the upper lip inclination even showed a slight deterioration of 7&#x0025;. This could be due to the fact that the Brons-Muli&#x00E9; analysis can indeed visualize preoperative problems, but cannot determine exactly how many millimeters or degrees must be corrected in order to achieve the normal range of values. Furthermore, it is usually not possible to change a single parameter without influencing other parameters. For example, an elongated chin cannot be moved arbitrarily far cranially at the expense of the gingival smile line. Thus, sometimes values outside the normal range have to be accepted during planning and surgery.</p>
<p>Nevertheless, by objectifying esthetic problems and limitations for surgical movements, the Brons-Muli&#x00E9; method can help to favorably influence planning and surgical outcome. For example, in case of a low Mandibula inclination in class II patients, there is clear evidence that surgical advancement of the chin results in a better esthetic outcome (<xref ref-type="bibr" rid="B19">19</xref>&#x2013;<xref ref-type="bibr" rid="B22">22</xref>). In the case of a severe chin retraction, the Brons-Muli&#x00E9; analysis can help to change a surgical plan from a pure mandibular advancement to a bimaxillary procedure. Using bimaxillary surgery, the chin can be moved further anteriorly, also by rotating the bimaxillary block around a transversal axis (<xref ref-type="bibr" rid="B23">23</xref>). Thus, an esthetically more favorable result can be achieved in many cases (<xref ref-type="bibr" rid="B24">24</xref>). Another example is the long face constellation with an increased mandibular inclination, which can be typically seen in Class III patients (<xref ref-type="bibr" rid="B25">25</xref>). In such cases, Brons-Muli&#x00E9; analysis may indicate the need to perform a bimaxillary procedure with a rotation of the bimaxillary block and a moderate setback of the mandible instead of a pure advancement of the maxilla, which even leads to an esthetically more favorable result of the facial profile (<xref ref-type="bibr" rid="B26">26</xref>, <xref ref-type="bibr" rid="B27">27</xref>).</p>
<p>But the Brons-Muli&#x00E9; analysis is not only suitable as a decision-making tool. Using Fisher&#x0027;s exact test (<xref ref-type="table" rid="T2">Table&#x00A0;2</xref>) and logistic regression analysis (<xref ref-type="table" rid="T3">Tables&#x00A0;3</xref>, <xref ref-type="table" rid="T4">4</xref> and <xref ref-type="fig" rid="F3">Figure&#x00A0;3</xref>) it was possible to show that certain initial conditions were obviously more difficult to correct by orthognathic surgery than others.</p>
<p><xref ref-type="table" rid="T3">Table&#x00A0;3</xref> shows that patients with an Angle Class III could often not be corrected sufficiently in the vertical dimension, while Class II patients often could not be treated successfully in the sagittal dimension with respect to the Mandibula inclination. Looking at the results of the logistic regression analysis, it becomes apparent that a preoperative long face constellation (<xref ref-type="table" rid="T4">Table&#x00A0;4</xref>: Success vertical/Pre-op. vertical: LF) and a preoperatively reduced Mandibula inclination (<xref ref-type="table" rid="T4">Table&#x00A0;4</xref>: Success MI/Pre-op. MI: L) had a significant influence on success. Odds ratio for both preoperative conditions was only 0.11, meaning that these constellations could only be corrected into the normal range with a significantly reduced probability. Thus, one constellation that was difficult to correct was the typical class III patient with a characteristic long face situation due to his progeny. Since bimaxillary surgery is often performed in anterior and caudal direction to protect the upper airway (<xref ref-type="bibr" rid="B28">28</xref>) and at the same time impaction of the jaws against the cranial base is complex and rather rarely performed, it becomes clear that it is difficult to sufficiently reduce an overly long lower face within the scope of bimaxillary surgery alone (<xref ref-type="fig" rid="F4">Figure&#x00A0;4</xref>). The same applies to a constellation of a too low mandibula inclination. Although the pogonion can be brought much further anteriorly by bimaxillary surgery, in many cases it cannot be brought forward enough to ensure that the Mandibula inclination actually reaches the normal range (<xref ref-type="fig" rid="F5">Figure&#x00A0;5</xref>). Both problems can be solved by an additional genioplasty (<xref ref-type="bibr" rid="B29">29</xref>), which can be performed as a bone reducing procedure in case of long face situations in Class III patients and as a bone augmenting procedure in Class II patients with decreased Mandibula inclination (<xref ref-type="bibr" rid="B30">30</xref>, <xref ref-type="bibr" rid="B31">31</xref>). Genioplasty can be performed either simultaneous to bimaxillary surgery or during the clinical course after 6 months (<xref ref-type="bibr" rid="B32">32</xref>). In the latter case, it is again useful to perform a further Brons-Muli&#x00E9; analysis to assess the chin.</p>
<fig id="F4" position="float"><label>Figure 4</label>
<caption><p>Brons-Muli&#x00E9; analysis of a patient with class III malocclusion pre- und postoperatively. The mandibula inclination could be optimized into the normal range. Despite the significant improvement of the facial profile, the long face constellation in the vertical dimension persisted.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="froh-06-1511342-g004.tif"/>
</fig>
<fig id="F5" position="float"><label>Figure 5</label>
<caption><p>Brons-Muli&#x00E9; analysis of a patient with class II malocclusion pre- and postoperatively. The vertical height could be optimized into the normal range. Despite the significant improvement of the facial profile, the mandibula inclination could not be corrected into the normal range.</p></caption>
<graphic xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="froh-06-1511342-g005.tif"/>
</fig>
</sec>
<sec id="s5" sec-type="conclusions"><label>5</label><title>Conclusions</title>
<p>Brons-Muli&#x00E9; analysis provides a simple tool for esthetic assessment of the facial soft tissue profile in addition to standard cephalometric analysis, which can be useful prior to orthognathic surgery. The postoperative application of the Brons-Muli&#x00E9; analysis can help to assess the quality of outcome and to identify possible planning deficits in orthognathic surgery. Often, a chin correction is an excellent additional procedure to fulfil remaining facial treatment objective after correction of the dentoskeletal mal-relation.</p>
</sec>
</body>
<back>
<sec id="s6" sec-type="data-availability"><title>Data availability statement</title>
<p>The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation.</p>
</sec>
<sec id="s7" sec-type="ethics-statement"><title>Ethics statement</title>
<p>The studies involving humans were approved by Ethics Committee at the Faculty of Medicine at Justus Liebig University Giessen. The studies were conducted in accordance with the local legislation and institutional requirements. The human samples used in this study were acquired from a by- product of routine care or industry. Written informed consent for participation was not required from the participants or the participants&#x0027; legal guardians/next of kin in accordance with the national legislation and institutional requirements. Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article.</p>
</sec>
<sec id="s8" sec-type="author-contributions"><title>Author contributions</title>
<p>SB: Conceptualization, Data curation, Investigation, Methodology, Project administration, Validation, Writing &#x2013; original draft. YN: Data curation, Investigation, Writing &#x2013; review &#x0026; editing. AW: Formal Analysis, Writing &#x2013; review &#x0026; editing. KK: Writing &#x2013; review &#x0026; editing. SR: Writing &#x2013; review &#x0026; editing. CB: Investigation, Writing &#x2013; review &#x0026; editing. ES: Investigation, Writing &#x2013; review &#x0026; editing. ND: Investigation, Writing &#x2013; review &#x0026; editing. RM: Methodology, Writing &#x2013; review &#x0026; editing. H-PH: Conceptualization, Methodology, Supervision, Validation, Writing &#x2013; review &#x0026; editing.</p>
</sec>
<sec id="s9" sec-type="funding-information"><title>Funding</title>
<p>The author(s) declare that no financial support was received for the research, authorship, and/or publication of this article.</p>
</sec>
<sec id="s10" sec-type="COI-statement"><title>Conflict of interest</title>
<p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p>
</sec>
<sec id="s13" sec-type="ai-statement"><title>Generative AI statement</title>
<p>The author(s) declare that no Generative AI was used in the creation of this manuscript.</p>
</sec>
<sec id="s12" sec-type="disclaimer"><title>Publisher&#x0027;s note</title>
<p>All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.</p>
</sec>
<sec id="s11" sec-type="supplementary-material"><title>Supplementary material</title>
<p>The Supplementary Material for this article can be found online at: <ext-link ext-link-type="uri" xlink:href="https://www.frontiersin.org/articles/10.3389/froh.2025.1511342/full#supplementary-material">https://www.frontiersin.org/articles/10.3389/froh.2025.1511342/full&#x0023;supplementary-material</ext-link></p>
<supplementary-material id="SD1" content-type="local-data">
<media mimetype="application" mime-subtype="pdf" xlink:href="Datasheet1.pdf"/></supplementary-material>
</sec>
<ref-list><title>References</title>
<ref id="B1"><label>1.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Arnett</surname><given-names>GW</given-names></name><name><surname>Bergman</surname><given-names>RT</given-names></name></person-group>. <article-title>Facial Keys to Orthodontic Diagnosis and Treatment Planning. Part I</article-title>. <source>Am J Orthod Dentofacial Orthop</source>. (<year>1993</year>) <volume>103</volume>:<fpage>299</fpage>&#x2013;<lpage>312</lpage>. <pub-id pub-id-type="doi">10.1016/0889-5406(93)70010-L</pub-id><pub-id pub-id-type="pmid">8480695</pub-id></citation></ref>
<ref id="B2"><label>2.</label><citation citation-type="book"><person-group person-group-type="author"><name><surname>Bass</surname><given-names>NM</given-names></name></person-group>. <source>The Aesthetic Analysis of the Face</source>. <publisher-loc>Oxford</publisher-loc>: <publisher-name>Oxford University Press</publisher-name> (<year>1991</year>). p. <fpage>343</fpage>&#x2013;<lpage>50</lpage>. <pub-id pub-id-type="doi">10.1093/ejo/13.5.343</pub-id></citation></ref>
<ref id="B3"><label>3.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kochel</surname><given-names>J</given-names></name><name><surname>Meyer-Marcotty</surname><given-names>P</given-names></name><name><surname>Strnad</surname><given-names>F</given-names></name><name><surname>Kochel</surname><given-names>M</given-names></name><name><surname>Stellzig-Eisenhauer</surname><given-names>A</given-names></name></person-group>. <article-title>3d soft tissue analysis&#x2013;part 1: sagittal parameters</article-title>. <source>J Orofac Orthop</source>. (<year>2010</year>) <volume>71</volume>(<issue>1</issue>):<fpage>40</fpage>&#x2013;<lpage>52</lpage>. <pub-id pub-id-type="doi">10.1007/s00056-010-9926-x</pub-id><pub-id pub-id-type="pmid">20135249</pub-id></citation></ref>
<ref id="B4"><label>4.</label><citation citation-type="book"><person-group person-group-type="author"><name><surname>Beckmann-van der Ven</surname><given-names>G</given-names></name><name><surname>Segner</surname><given-names>D</given-names></name><name><surname>Hasund</surname><given-names>A</given-names></name></person-group>. <source>Die Erfassung Der Gesichtsweichteiloberfl&#x00E4;che in Drei Dimensionen Unter Besonderer Ber&#x00FC;cksichtigung Der Mandibula</source>. <publisher-loc>Fortschritte der Kieferorthop&#x00E4;die</publisher-loc>: <publisher-name>Springer-Verlag</publisher-name> (<year>1985</year>). p. <fpage>279</fpage>&#x2013;<lpage>87</lpage>. <pub-id pub-id-type="doi">10.1007/BF02164205</pub-id></citation></ref>
<ref id="B5"><label>5.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>H&#x00F6;nn</surname><given-names>M</given-names></name><name><surname>G&#x00F6;z</surname><given-names>G</given-names></name></person-group>. <article-title>The ideal of facial beauty: a review</article-title>. <source>J Orofac Orthop</source>. (<year>2007</year>) <volume>68</volume>:<fpage>6</fpage>&#x2013;<lpage>16</lpage>. <pub-id pub-id-type="doi">10.1007/s00056-007-0604-6</pub-id></citation></ref>
<ref id="B6"><label>6.</label><citation citation-type="book"><person-group person-group-type="author"><name><surname>Canut</surname><given-names>J</given-names></name></person-group>. <article-title>Extraktion oder nichtextraktion: &#x00E4;sthetische erw&#x00E4;gungen</article-title>. In: <person-group person-group-type="editor"><name><surname>Bolender</surname><given-names>C</given-names></name><name><surname>G</surname><given-names>B</given-names></name><name><surname>B</surname><given-names>Y</given-names></name></person-group>, editors. <source>Extraction Versus Nonextraction</source>. <publisher-loc>M&#x00FC;nchen</publisher-loc>: <publisher-name>Neuer Merkur Verlag</publisher-name> (<year>1995</year>). p. <fpage>203</fpage>&#x2013;<lpage>13</lpage>.</citation></ref>
<ref id="B7"><label>7.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Reuther</surname><given-names>J</given-names></name></person-group>. <article-title>Orthognathe chirurgie: skelettverlagernde operationen</article-title>. <source>Mund Kiefer Gesichtschir</source>. (<year>2013</year>) <volume>4</volume>:<fpage>S237</fpage>&#x2013;<lpage>S48</lpage>. <pub-id pub-id-type="doi">10.1007/PL00014545</pub-id></citation></ref>
<ref id="B8"><label>8.</label><citation citation-type="book"><person-group person-group-type="author"><name><surname>Brons</surname><given-names>R</given-names></name></person-group>. <source>Facial Harmony: Standards for Orthognathic Surgery and Orthodontics</source>. <publisher-loc>Chicago</publisher-loc>: <publisher-name>Quintessence Publishing Co Inc. U.S.</publisher-name> (<year>1998</year>).</citation></ref>
<ref id="B9"><label>9.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Freihofer</surname><given-names>HP</given-names></name><name><surname>Mooren</surname><given-names>RE</given-names></name></person-group>. <article-title>Profiloplasty: variations in personal views</article-title>. <source>J Craniomaxillofac Surg</source>. (<year>1997</year>) <volume>25</volume>(<issue>5</issue>):<fpage>249</fpage>&#x2013;<lpage>53</lpage>. <pub-id pub-id-type="doi">10.1016/s1010-5182(97)80061-3</pub-id><pub-id pub-id-type="pmid">9368859</pub-id></citation></ref>
<ref id="B10"><label>10.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Mooren</surname><given-names>RE</given-names></name><name><surname>Freihofer</surname><given-names>HP</given-names></name><name><surname>Borstlap</surname><given-names>WA</given-names></name></person-group>. <article-title>Reproducibility of aimed-at profiles</article-title>. <source>J Craniomaxillofac Surg</source>. (<year>1998</year>) <volume>26</volume>(<issue>1</issue>):<fpage>22</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1016/s1010-5182(98)80031-0</pub-id><pub-id pub-id-type="pmid">9563591</pub-id></citation></ref>
<ref id="B11"><label>11.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Gu</surname><given-names>JT</given-names></name><name><surname>Avilla</surname><given-names>D</given-names></name><name><surname>Devcic</surname><given-names>Z</given-names></name><name><surname>Karimi</surname><given-names>K</given-names></name><name><surname>Wong</surname><given-names>BJF</given-names></name></person-group>. <article-title>Association of frontal and lateral facial attractiveness</article-title>. <source>JAMA Facial Plast Surg</source>. (<year>2018</year>) <volume>20</volume>(<issue>1</issue>):<fpage>19</fpage>&#x2013;<lpage>23</lpage>. <pub-id pub-id-type="doi">10.1001/jamafacial.2017.0710</pub-id><pub-id pub-id-type="pmid">28772308</pub-id></citation></ref>
<ref id="B12"><label>12.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Bamber</surname><given-names>MA</given-names></name><name><surname>Harris</surname><given-names>M</given-names></name><name><surname>Nacher</surname><given-names>C</given-names></name></person-group>. <article-title>A validation of two orthognathic model surgery techniques</article-title>. <source>J Orthod</source>. (<year>2001</year>) <volume>28</volume>:<fpage>135</fpage>&#x2013;<lpage>42</lpage>. <pub-id pub-id-type="doi">10.1093/ortho/28.2.135</pub-id><pub-id pub-id-type="pmid">11395528</pub-id></citation></ref>
<ref id="B13"><label>13.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Aboul-Hosn Centenero</surname><given-names>S</given-names></name><name><surname>Hern&#x00E1;ndez-Alfaro</surname><given-names>F</given-names></name></person-group>. <article-title>3d Planning in orthognathic surgery: cad/cam surgical splints and prediction of the soft and hard tissues results E our experience in 16 cases</article-title>. <source>J Craniomaxillofac Surg</source>. (<year>2012</year>) <volume>40</volume>:<fpage>162</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1016/j.jcms.2011.03.014</pub-id><pub-id pub-id-type="pmid">21458285</pub-id></citation></ref>
<ref id="B14"><label>14.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Krenkel</surname><given-names>C</given-names></name><name><surname>Lixl</surname><given-names>G</given-names></name></person-group>. <article-title>Model surgical apparatus for planning and simulation of maxillary and mandibular osteotomies</article-title>. <source>Zahn&#x00E4;rztl Prax</source>. (<year>1991</year>) <volume>42</volume>:<fpage>471</fpage>&#x2013;<lpage>3</lpage>.</citation></ref>
<ref id="B15"><label>15.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>H&#x00F6;nn</surname><given-names>M</given-names></name><name><surname>Dietz</surname><given-names>K</given-names></name><name><surname>Godt</surname><given-names>A</given-names></name><name><surname>G&#x00F6;z</surname><given-names>G</given-names></name></person-group>. <article-title>Perceived relative attractiveness of facial profiles with varying degrees of skeletal anomalies</article-title>. <source>J Orofac Orthop</source>. (<year>2005</year>) <volume>66</volume>:<fpage>187</fpage>&#x2013;<lpage>96</lpage>. <pub-id pub-id-type="doi">10.1007/s00056-005-0445-0</pub-id></citation></ref>
<ref id="B16"><label>16.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Steenen</surname><given-names>SA</given-names></name><name><surname>van Teeseling</surname><given-names>RA</given-names></name><name><surname>Vulink</surname><given-names>NC</given-names></name><name><surname>Becking</surname><given-names>AG</given-names></name></person-group>. <article-title>Psychological aspects of orthognathic surgery</article-title>. <source>Ned Tijdschr Tandheelkd</source>. (<year>2014</year>) <volume>121</volume>(<issue>9</issue>):<fpage>446</fpage>&#x2013;<lpage>52</lpage>. <pub-id pub-id-type="doi">10.5177/ntvt.2014.09.14114</pub-id><pub-id pub-id-type="pmid">25296471</pub-id></citation></ref>
<ref id="B17"><label>17.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Brucoli</surname><given-names>M</given-names></name><name><surname>Zeppegno</surname><given-names>P</given-names></name><name><surname>Benech</surname><given-names>R</given-names></name><name><surname>Boffano</surname><given-names>P</given-names></name><name><surname>Benech</surname><given-names>A</given-names></name></person-group>. <article-title>Psychodynamic features associated with orthognathic surgery: a comparison between conventional orthognathic treatment and &#x201C;surgery-first&#x201D; approach</article-title>. <source>J Oral Maxillofac Surg</source>. (<year>2019</year>) <volume>77</volume>(<issue>1</issue>):<fpage>157</fpage>&#x2013;<lpage>63</lpage>. <pub-id pub-id-type="doi">10.1016/j.joms.2018.06.005</pub-id><pub-id pub-id-type="pmid">30599884</pub-id></citation></ref>
<ref id="B18"><label>18.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Wang</surname><given-names>BL</given-names></name><name><surname>Yang</surname><given-names>ML</given-names></name></person-group>. <article-title>Psychological status of patients with skeletal class iii malocclusion undergoing bimaxillary surgery: a comparative study</article-title>. <source>Medicine</source>. (<year>2024</year>) <volume>103</volume>(<issue>34</issue>):<fpage>e39435</fpage>. <pub-id pub-id-type="doi">10.1097/md.0000000000039435</pub-id><pub-id pub-id-type="pmid">39183428</pub-id></citation></ref>
<ref id="B19"><label>19.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Shelly</surname><given-names>AD</given-names></name><name><surname>Southard</surname><given-names>TE</given-names></name><name><surname>Southard</surname><given-names>KA</given-names></name><name><surname>Casko</surname><given-names>JS</given-names></name><name><surname>Jakobsen</surname><given-names>JR</given-names></name><name><surname>Fridrich</surname><given-names>KL</given-names></name><etal/></person-group> <article-title>Evaluation of profile esthetic change with mandibular advancement surgery</article-title>. <source>Am J Orthod Dentofacial Orthop</source>. (<year>2000</year>) <volume>117</volume>(<issue>6</issue>):<fpage>630</fpage>&#x2013;<lpage>7</lpage>. <pub-id pub-id-type="doi">10.1016/S0889-5406(00)70171-5</pub-id><pub-id pub-id-type="pmid">10842105</pub-id></citation></ref>
<ref id="B20"><label>20.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Tsang</surname><given-names>ST</given-names></name><name><surname>McFadden</surname><given-names>LR</given-names></name><name><surname>Wiltshire</surname><given-names>WA</given-names></name><name><surname>Pershad</surname><given-names>N</given-names></name><name><surname>Baker</surname><given-names>AB</given-names></name></person-group>. <article-title>Profile changes in orthodontic patients treated with mandibular advancement surgery</article-title>. <source>Am J Orthod Dentofacial Orthop</source>. (<year>2009</year>) <volume>135</volume>(<issue>1</issue>):<fpage>66</fpage>&#x2013;<lpage>72</lpage>. <pub-id pub-id-type="doi">10.1016/j.ajodo.2007.01.033</pub-id><pub-id pub-id-type="pmid">19121503</pub-id></citation></ref>
<ref id="B21"><label>21.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Klaus</surname><given-names>K</given-names></name><name><surname>Heumann</surname><given-names>C</given-names></name><name><surname>Ruf</surname><given-names>S</given-names></name></person-group>. <article-title>Effect of orthognathic surgery on profile esthetics in class ii:1 malocclusions</article-title>. <source>J Orofac Orthop</source>. (<year>2017</year>) <volume>78</volume>(<issue>6</issue>):<fpage>472</fpage>&#x2013;<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1007/s00056-017-0099-8</pub-id><pub-id pub-id-type="pmid">28660422</pub-id></citation></ref>
<ref id="B22"><label>22.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Raposo</surname><given-names>R</given-names></name><name><surname>Peleteiro</surname><given-names>B</given-names></name><name><surname>Pa&#x00E7;o</surname><given-names>M</given-names></name><name><surname>Pinho</surname><given-names>T</given-names></name></person-group>. <article-title>Orthodontic camouflage versus orthodontic-orthognathic surgical treatment in class ii malocclusion: a systematic review and meta-analysis</article-title>. <source>Int J Oral Maxillofac Surg</source>. (<year>2018</year>) <volume>47</volume>(<issue>4</issue>):<fpage>445</fpage>&#x2013;<lpage>55</lpage>. <pub-id pub-id-type="doi">10.1016/j.ijom.2017.09.003</pub-id><pub-id pub-id-type="pmid">28966066</pub-id></citation></ref>
<ref id="B23"><label>23.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Balasubramanian</surname><given-names>B</given-names></name><name><surname>Sundaram</surname><given-names>NR</given-names></name><name><surname>Boovaraghavan</surname><given-names>S</given-names></name><name><surname>Gali</surname><given-names>RS</given-names></name><name><surname>Venkatachalapathy</surname><given-names>S</given-names></name><name><surname>Natarajan</surname><given-names>K</given-names></name></person-group>. <article-title>Management of class ii hyperdivergent mandible by surgically altering occlusal plane pattern through counterclockwise rotation of mandible</article-title>. <source>J Contemp Dent Pract</source>. (<year>2021</year>) <volume>22</volume>(<issue>9</issue>):<fpage>1048</fpage>&#x2013;<lpage>54</lpage>. <pub-id pub-id-type="doi">10.5005/jp-journals-10024-3146</pub-id><pub-id pub-id-type="pmid">35000951</pub-id></citation></ref>
<ref id="B24"><label>24.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ruslin</surname><given-names>M</given-names></name><name><surname>Hajrah Yusuf</surname><given-names>AS</given-names></name><name><surname>Forouzanfar</surname><given-names>T</given-names></name><name><surname>Greebe</surname><given-names>RB</given-names></name><name><surname>Tuinzing</surname><given-names>DB</given-names></name><name><surname>Thamrin</surname><given-names>SA</given-names></name><etal/></person-group> <article-title>One-Year stability of the mandibular advancement and counterclockwise rotation for correction of the skeletal class ii malocclusion and high mandibular plane angle: dental and skeletal aspect</article-title>. <source>Biomed J</source>. (<year>2022</year>) <volume>45</volume>(<issue>1</issue>):<fpage>206</fpage>&#x2013;<lpage>14</lpage>. <pub-id pub-id-type="doi">10.1016/j.bj.2021.02.005</pub-id><pub-id pub-id-type="pmid">35346613</pub-id></citation></ref>
<ref id="B25"><label>25.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ellis</surname><given-names>E</given-names></name><name><surname>McNamara</surname><given-names>JA</given-names></name></person-group>. <article-title>Components of adult class iii open-bite malocclusion</article-title>. <source>Am J Orthod</source>. (<year>1984</year>) <volume>86</volume>:<fpage>277</fpage>&#x2013;<lpage>90</lpage>. <pub-id pub-id-type="doi">10.1016/0002-9416(84)90138-6</pub-id><pub-id pub-id-type="pmid">6592976</pub-id></citation></ref>
<ref id="B26"><label>26.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Cao</surname><given-names>Y</given-names></name><name><surname>Zhou</surname><given-names>Y</given-names></name><name><surname>Li</surname><given-names>Z</given-names></name></person-group>. <article-title>Surgical-orthodontic treatment of class iii patients with long face problems: a retrospective study</article-title>. <source>J Oral Maxillofac Surg</source>. (<year>2009</year>) <volume>67</volume>(<issue>5</issue>):<fpage>1032</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1016/j.joms.2008.11.017</pub-id><pub-id pub-id-type="pmid">19375014</pub-id></citation></ref>
<ref id="B27"><label>27.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Kor</surname><given-names>HS</given-names></name><name><surname>Yang</surname><given-names>HJ</given-names></name><name><surname>Hwang</surname><given-names>SJ</given-names></name></person-group>. <article-title>Relapse of skeletal class iii with anterior open bite after bimaxillary orthognathic surgery depending on maxillary posterior impaction and mandibular counterclockwise rotation</article-title>. <source>J Craniomaxillofac Surg</source>. (<year>2014</year>) <volume>42</volume>(<issue>5</issue>):<fpage>e230</fpage>&#x2013;<lpage>8</lpage>. <pub-id pub-id-type="doi">10.1016/j.jcms.2013.08.013</pub-id><pub-id pub-id-type="pmid">24954529</pub-id></citation></ref>
<ref id="B28"><label>28.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>He</surname><given-names>J</given-names></name><name><surname>Wang</surname><given-names>Y</given-names></name><name><surname>Hu</surname><given-names>H</given-names></name><name><surname>Liao</surname><given-names>Q</given-names></name><name><surname>Zhang</surname><given-names>W</given-names></name><name><surname>Xiang</surname><given-names>X</given-names></name><etal/></person-group> <article-title>Impact on the upper airway space of different types of orthognathic surgery for the correction of skeletal class iii malocclusion: a systematic review and meta-analysis</article-title>. <source>Int J Surg</source>. (<year>2017</year>) <volume>38</volume>:<fpage>31</fpage>&#x2013;<lpage>40</lpage>. <pub-id pub-id-type="doi">10.1016/j.ijsu.2016.12.033</pub-id><pub-id pub-id-type="pmid">28027997</pub-id></citation></ref>
<ref id="B29"><label>29.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Ramanathan</surname><given-names>M</given-names></name><name><surname>Panneerselvam</surname><given-names>E</given-names></name><name><surname>Parameswaran</surname><given-names>A</given-names></name><name><surname>Kanno</surname><given-names>T</given-names></name></person-group>. <article-title>Genioplasty in contemporary orthognathic surgery</article-title>. <source>Oral Maxillofac Surg Clin North Am</source>. (<year>2023</year>) <volume>35</volume>(<issue>1</issue>):<fpage>97</fpage>&#x2013;<lpage>114</lpage>. <pub-id pub-id-type="doi">10.1016/j.coms.2022.06.009</pub-id><pub-id pub-id-type="pmid">36336599</pub-id></citation></ref>
<ref id="B30"><label>30.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>San Miguel Moragas</surname><given-names>J</given-names></name><name><surname>Oth</surname><given-names>O</given-names></name><name><surname>B&#x00FC;ttner</surname><given-names>M</given-names></name><name><surname>Mommaerts</surname><given-names>MY</given-names></name></person-group>. <article-title>A systematic review on soft-to-hard tissue ratios in orthognathic surgery part ii: chin procedures</article-title>. <source>J Craniomaxillofac Surg</source>. (<year>2015</year>) <volume>43</volume>(<issue>8</issue>):<fpage>1530</fpage>&#x2013;<lpage>40</lpage>. <pub-id pub-id-type="doi">10.1016/j.jcms.2015.07.032</pub-id><pub-id pub-id-type="pmid">26321067</pub-id></citation></ref>
<ref id="B31"><label>31.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Park</surname><given-names>JY</given-names></name><name><surname>Kim</surname><given-names>MJ</given-names></name><name><surname>Hwang</surname><given-names>SJ</given-names></name></person-group>. <article-title>Soft tissue profile changes after setback genioplasty in orthognathic surgery patients</article-title>. <source>J Craniomaxillofac Surg</source>. (<year>2013</year>) <volume>41</volume>(<issue>7</issue>):<fpage>657</fpage>&#x2013;<lpage>64</lpage>. <pub-id pub-id-type="doi">10.1016/j.jcms.2013.01.005</pub-id><pub-id pub-id-type="pmid">23395297</pub-id></citation></ref>
<ref id="B32"><label>32.</label><citation citation-type="journal"><person-group person-group-type="author"><name><surname>Torgersbr&#x00E5;ten</surname><given-names>N</given-names></name><name><surname>Stenvik</surname><given-names>A</given-names></name><name><surname>Espeland</surname><given-names>L</given-names></name></person-group>. <article-title>Bimaxillary surgery to correct high-angle class ii malocclusion: does a simultaneous genioplasty affect long-term stability?</article-title> <source>Eur J Orthod</source>. (<year>2020</year>) <volume>42</volume>(<issue>4</issue>):<fpage>426</fpage>&#x2013;<lpage>33</lpage>. <pub-id pub-id-type="doi">10.1093/ejo/cjz055</pub-id></citation></ref></ref-list>
</back>
</article>