AUTHOR=Kotsantis Ioannis , Boulouta Anna , Economopoulou Panagiota , Kyriazoglou Anastasios , Karamagkiolas Sotirios , Kyrkasiadou Maria , Gavrielatou Niki , Anastasiou Maria , Pantazopoulos Anastasios , Psyrri Amanda 

TITLE=Wernicke’s encephalopathy in a patient with adenoid cystic carcinoma: case report and literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1723422

DOI=10.3389/fonc.2025.1723422

ISSN=2234-943X

ABSTRACT=Wernicke’s encephalopathy is an acute neurologic disorder caused by thiamine (vitamin B1) deficiency, which is most commonly associated with alcoholism. Rare cases of Wernicke’s encephalopathy have been described in cancer patients, mostly with gastrointestinal and hematologic malignancies. Head and neck cancer patients frequently have reduced oral intake as a direct result of their tumor or from chemoradiation treatments. We report a case of Wernicke’s encephalopathy in a 44-year-old woman with adenoid cystic carcinoma following chemoradiotherapy. Through a literature review we identified additional cases of Wernicke’s encephalopathy in head and neck cancer patients, highlighting the importance of recognizing nutritional deficiencies and associated complications. The findings emphasize the need for heightened awareness regarding the risk of thiamine deficiency in cancer patients, particularly those experiencing poor nutritional intake due to treatment-related side effects. Prompt diagnosis and intervention are critical to prevent serious morbidity and mortality associated with this condition.