AUTHOR=Zhang Qun-xian , Guo Qiang , Li Dan , Liu Tao , Luo Xiang-Yu , Liu Hua , Zhou Jun , Zeng Min , Zhang Jun , Lin Chen-Yi 

TITLE=Therapeutic dilemmas in young children with lung cancer: a case report and literature review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1704977

DOI=10.3389/fonc.2025.1704977

ISSN=2234-943X

ABSTRACT=With the widespread use of plain chest CT scans, the detection of early-stage lung cancer has risen. This manuscript reviews surgical strategies for young patients with early-stage ground-glass nodules (GGNs) indicative of lung adenocarcinoma (LUAD), based on a case study and literature review, aiming to provide clinical insights for management. A 15-year-old adolescent male patient who underwent a routine chest CT, which revealed a ~0.7 cm GGN in the right upper lung. A follow-up CT on April 20, 2025, showed interval growth to approximately 9 × 8 mm in the apical segment. On July 1, 2025, the patient underwent wedge resection of the right upper lung via VATS. Postoperative pathology confirmed minimally invasive LUAD. The patient recovered well and was discharged the following day. A review of literature (2020–2025) identified eight cases of lung cancer in patients ≤18 years. Two patients did not undergo operation due to advanced disease. The remaining underwent surgical resection, with two requiring adjuvant therapy. In summary, lung cancer should be considered in the differential diagnosis of pulmonary nodules detected on plain chest CT. The decreasing age of onset underscores the need for timely intervention to prevent delayed treatment and improve prognosis.