AUTHOR=Hobson Jared , Grams Michael P. , Gicobi Joanina K. , Wigle Dennis , Kottschade Lisa A. , Durham Lindsey A. , Corbin Kimberly , Dong Haidong , Markovic Svetomir N. , Park Sean S. 

TITLE=Case Report: Complete pathologic response in advanced melanoma with SFRT and dual checkpoint inhibition

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1697902

DOI=10.3389/fonc.2025.1697902

ISSN=2234-943X

ABSTRACT=Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape for advanced melanoma, though response rates remain limited in bulky disease. Herein, we report the case of a complete pathologic response following combination spatially fractionated radiation therapy (SFRT) and dual nivolumab and ipilimumab for a 12 cm right lung melanoma mass, with subsequent lobectomy revealing no viable tumor cells. Now disease free 2.5 years after treatment, including more than 1 year off all systemic therapy, this case highlights the potential synergy between SFRT and immunotherapy in advanced melanoma management.