AUTHOR=Penagaricano Jose , Nakashima Justyn Y. 

TITLE=Case Report: Early experience with hypoxia-targeted SBRT-based partial tumor irradiation in large and bulky tumors

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1697888

DOI=10.3389/fonc.2025.1697888

ISSN=2234-943X

ABSTRACT=Large and bulky tumors possess poor prognostic characteristics that make tumor control difficult. Stereotactic body radiotherapy (SBRT)-based partial tumor irradiation targeting the hypoxic segment (SBRT-PATHY) has been described as a spatially fractionated radiotherapy technique that induces both bystander and abscopal effects by sparing the peritumoral immune microenvironment, thus minimizing the negative effects of radiation-induced lymphopenia. These case reports aim to present our early experience with four cases utilizing SBRT-PATHY at our institution.