AUTHOR=Li Youjia , Su Liyang , Zhang Qingquan , Liu Zhonghua 

TITLE=Development and validation of a nomogram for differentiating granulomatous lobular mastitis from ductal carcinoma in situ

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1668908

DOI=10.3389/fonc.2025.1668908

ISSN=2234-943X

ABSTRACT=BackgroundGranulomatous lobular mastitis (GLM) frequently mimics ductal carcinoma in situ (DCIS) in clinical presentation and imaging characteristics, leading to misdiagnosis and unnecessary aggressive interventions. This study aimed to develop and validate a practical nomogram for differentiating GLM from DCIS.MethodsWe conducted a retrospective study at Quanzhou First Hospital from January 2020 to April 2025, including 290 patients with histopathologically confirmed GLM (n=128) or DCIS (n=162). Patients were randomly divided into training (n=203) and validation (n=87) sets. Clinical, laboratory, and ultrasound features were analyzed using univariate and multivariate logistic regression to identify independent predictors. A nomogram was constructed and evaluated using receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis.ResultsSix independent predictors were incorporated into the final nomogram: age, lesion size, margin characteristics, microcalcifications, posterior acoustic enhancement, and peri-lesional flow. The nomogram demonstrated excellent discriminative performance with areas under the ROC curve of 0.95 (95% CI: 0.92-0.98) in the training set and 0.93 (95% CI: 0.88-0.98) in the validation set. At optimal thresholds, the model achieved sensitivity of 92% and specificity of 89% in the training set, and 89% and 79% respectively in the validation set. Calibration plots confirmed high predictive accuracy, and decision curve analysis demonstrated substantial clinical benefit across clinically relevant threshold probabilities.ConclusionsThis novel nomogram represents a diagnostic tool specifically designed for GLM versus DCIS differentiation. Its reliance on widely available clinical and ultrasound parameters makes it particularly valuable for resource-limited settings, potentially reducing unnecessary biopsies and associated patient morbidity.