AUTHOR=Li Kun , Lu Qi , Guo Xiaoyan , Kou Ting , Chen Jiyue , Yang Shiming , Shen Weidong 

TITLE=Multifactorial analysis and construction of a nomogram model for postoperative recurrence of glomus jugulare tumor

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1662079

DOI=10.3389/fonc.2025.1662079

ISSN=2234-943X

ABSTRACT=BackgroundTo derive and validate a prognostic nomogram for predicting postoperative recurrence in patients with glomus jugulare tumor(GJT) to assist clinical decision-making.MethodsA retrospective analysis was conducted on the clinical data of a total of 318 patients diagnosed with GJT at a single tertiary medical center. The study collected information on patient demographics, clinical symptoms and signs, examination results, and the extent of tumor growth. Patients were categorized into two groups based on DFS (Disease - free survival): those who experienced recurrence and those who did not. A nomogram model was developed using logistic regression to analyze the risk of postoperative recurrence.ResultsMultivariate logistic regression analysis identified age, immunohistochemical expression levels of Ki-67 and S-100 and tumor invasion extent were significantly associated as independent predictors. These independent predictors were incorporated into a nomogram. The logistic regression-based nomogram showed excellent predictive accuracy of the nomogram model in the training set, validation set, and test set, with corresponding areas under the curve (AUC) of 0.863, 0.711, and 0.784, respectively.ConclusionsThe nomogram effectively predicts GJT recurrence, validated internally and externally, aiding clinical risk stratification.