Front. Oncol. Frontiers in Oncology Front. Oncol. 2234-943X Frontiers Media S.A. 10.3389/fonc.2025.1657780 Oncology Correction Correction: MiR-29b-3p inhibits migration and invasion of papillary thyroid carcinoma by down-regulating COL1A1 and COL5A1 Wang Congjun 1 2 † Wang Ye 1 2 † Fu Zhao 1 2 Huang Weijia 1 2 Yu Zhu 1 2 Wang Jiancheng 1 2 Zheng Kaitian 1 2 Zhang Siwen 1 2 Li Shen 3 Chen Junqiang 1 2 * 1 Department of Gastrointestinal Gland Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, China 2 Clinical Research Lab, Guangxi Key Laboratory of Enhanced Recovery After Surgery for Gastrointestinal Cancer, Nanning, China 3 Department of Gastrointestinal, Hernia and Enterofistula Surgery, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, China

Edited and reviewed by: Carlos Pérez-Plasencia, National Autonomous University of Mexico, Mexico

*Correspondence: Junqiang Chen, chenjunqiang@gxmu.edu.cn

†These authors have contributed equally to this work and share first authorship

 03 10 2025 2025 15 1657780 01 07 2025 19 09 2025 Copyright © 2025 Wang, Wang, Fu, Huang, Yu, Wang, Zheng, Zhang, Li and Chen. 2025 Wang, Wang, Fu, Huang, Yu, Wang, Zheng, Zhang, Li and Chen

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 A Correction on MiR-29b-3p inhibits migration and invasion of papillary thyroid carcinoma by down-regulating COL1A1 and COL5A1 By Wang C, Wang Y, Fu Z, Huang W, Yu Z, Wang J, Zheng K, Zhang S, Li S and Chen J (2022). Front. Oncol. 12:837581. doi: 10.3389/fonc.2022.837581 microRNAs miR-29b-3p papillary thyroid carcinoma downregulation COL1A1 COL5A1 gene expression section-in-acceptance Molecular and Cellular Oncology

In the published article, there was an error in Figure 2 as published. In Figure 2E , the EDU experimental result images for the B-CPAP cell line NC inhibitor treatment group were misplaced. The corrected Figure 2 and its caption appear below.

miR-29b-3p inhibits PTC cell migration and invasion in vitro. (A) Expression of miR-29b-3p was verified by qRT-PCR in PTC cell lines (K1, KTC-1, TPC-1, and B-CPAP) and normal thyroid cell lines (Nthyori3–1); two lowly expressing (K1 and B-CPAP) cell lines were selected for further study. (B) The knockdown and overexpression efficiencies of miR-29b-3p was verified by qRT-PCR after transfection with miR-29b-3p mimic/inhibitor or NC mimic/inhibitor. Cell proliferation ability of PTC cells was determined by CCK-8 assays (C, D) and EdU assays (E–G) after miR-29b-3p overexpression or knockdown. The effects of miR-29b-3p overexpression and knockdown in PTC cells on cell migration and invasion were analyzed by wound healing assays (H) and Transwell assays (I). (J, L) Results of the Transwell assays and wound healing assays. In the figure, **p < 0.01, ***p < 0.001,****p < 0.0001.

A composite of graphs and microscopy images related to miR-29b-3p research. Graphs (A-D, F, G, J-L) depict relative expression, cell numbers, proliferation, healing rate, migration, and invasion across different conditions and cell lines. Microscopy images (E, H, I) show cell proliferation visualizations, wound healing, and cell migration and invasion assays, comparing NC mimic, miR-29b-3p mimic, NC inhibitor, and miR-29b-3p inhibitor in K1 and B-CPAP cell lines. Statistical significance is indicated with asterisks.

In the published article, there was an error in Figure 4 as published. In Figure 4N , image arrangement errors occurred for the K1 cell line miR-29b-3p Mimic treatment group and the B-CPAP cell line NC Mimic, miR-29b-3p Mimic, and miR-29b-3p Mimic + OE COL5A1 treatment groups. The corrected Figure 4 and its caption appear below.

Overexpression of COL1A1 or COL5A1 partially blocks the suppressive effects of miR-29b-3p on invasion in PTC cells. (A, B) qRT-PCR and (C) Western blot were performed to assess the transfection efficiency of COL1A1 and COL5A1 overexpression plasmids. (D, E) Quantification of COL1A1 and COL5A1 levels in Western blot normalized over GAPDH and Vinculin. The wound healing assays (F) and Transwell assays (G) demonstrated that the overexpression of COL1A1 and COL5A1 could efficiently alleviate the miR-29b-3p mimic-induced inhibition of the migration and invasion activities of K1 and B-CPAP cells. (H–J) Quantified results of the wound-healing assays and Transwell assays. Inhibition of miR-29b-3p mimic-induced EMT by overexpressed COL1A1 or COL5A1; the EMT-related proteins were investigated by (K) Western blot and (N) immunofluorescence. (L, M) The EMT-related proteins expression for each group was analyzed by Image J software. In the figure, *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.

Graphs and images showing experimental data on gene expression and protein levels related to COL1A1 and COL5A1 in K1 and B-CPAP cell lines. Panels A and B display bar graphs of relative expression of COL1A1 and COL5A1. Panel C shows a Western blot for protein levels. Panels D and E present bar graphs of relative protein levels. Panel F has wound healing assay images, and Panel G shows migration and invasion assay results. Panels H to J contain related bar graphs for wound healing, migration, and invasion rates. Panel K is another Western blot for EMT markers. Panels L and M represent bar graphs for EMT marker expression. Panel N includes fluorescence microscopy images showing E-cadherin, Vimentin, DAPI staining, and merged images in K1 and B-CPAP cells.

In the published article, there was an error in Figure 5 as published. In Figure 5L , the immunofluorescence experimental result images for the B-CPAP cell line si-COL1A1–2 treatment group were misplaced during assembly. The corrected Figure 5 and its caption appear below.

Down-regulating COL1A1 or COL5A1 expression can inhibit migration, invasion, and EMT in PTC cells. The knockdown efficiency of COL1A1 and COL5A1 were analyzed by (A, B) qRT-PCR and (C–E) and Western blotting. Additionally, (F) wound healing and (G) Transwell assays were conducted to evaluate PTC cells migration and invasion, which proved that both si-COL1A1–2 and si-COL5A1–1 significantly impaired migration and invasion ability in K1 and B-CPAP cells. (H–J) The statistical results of wound healing assays and Transwell assays. (K) Western blot and (L) immunofluorescence analyses were performed to determine the expression of EMT-related proteins detection in PTC cells transfected with si-COL1A1–2 and si-COL5A1–1. (M, N) Western blotting assay showing the protein expression levels of EMT-related in PTC cells. In the figure, ***p < 0.001, ****p < 0.0001.

Scientific presentation on the effects of silencing COL1A1 and COL5A1 in K1 and B-CPAP cell lines. Panels A and B show bar charts of decreased expression after silencing. Panel C displays Western blot results. Panels D and E show protein levels. Panels F and G illustrate wound healing and migration assays. Panels H to J quantify wound healing, migration, and invasion. Panel K exhibits additional Western blot data. Panel L is immunofluorescence staining for E-cadherin, vimentin, and nuclei (DAPI). Panels M and N present bar charts of EMT marker expression. Data indicates significant reduction in expression and invasion capabilities.

The original version of this article has been updated.

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