AUTHOR=Shen Yi , Liu Liping , Ma Shuang , Ban Xiaohua , Chen Shaoxian , Dai Zhuozhi , Lin Shaofan , Huang Kainan , Duan Xiaohui , Lin Daiying 

TITLE=Multiparametric MRI-based radiomics and deep learning for differentiating uterine serous carcinoma from endometrioid carcinoma: a multicenter retrospective study

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1655384

DOI=10.3389/fonc.2025.1655384

ISSN=2234-943X

ABSTRACT=BackgroundUterine serous carcinoma (USC) and endometrioid endometrial carcinoma (EEC) are distinct subtypes of endometrial cancer with markedly different prognoses and management strategies. Accurate preoperative differentiation between USC and EEC is of great significance for tailoring surgical planning and adjuvant therapy.PurposeTo develop and validate a multiparametric MRI-based radiomics and deep learning (DL) model for preoperative distinguishing USC from EEC.MethodsA total of 210 patients (68 USCs and 142 EECs) from four hospitals who underwent preoperative MRI were enrolled in this retrospective study. Features from radiomics and deep learning were extracted using T2-weighted imaging (T2WI), diffusion-weighted imaging (DWI), and contrast enhanced MRI (CE-MRI). The least absolute shrinkage and selection operator (LASSO) analysis was employed to identify the most valuable features. Clinical-radiological characteristics, radiomics and DL features were constructed using a support vector machine (SVM) algorithm. The models were evaluated using receiver operating characteristic (ROC) and decision curve analysis (DCA).ResultsThe all-combined model of clinical-radiological characteristics, radiomics and DL features showed better discrimination ability than either alone. The all-combined model demonstrated superior classification performance, achieving an AUC of 0.957 (95% CI: 0.904–1.000) on the internal-testing set and an AUC of 0.880 (95% CI: 0.800–0.961) on the external-testing set. The DLR model demonstrated superior predictive performance compared to the clinical-radiological model, although the differences were not statistically significant in both the internal-testing set (AUC = 0.908 vs. 0.861, p = 0.504) and the external-testing set (AUC = 0.767 vs. 0.700, p = 0.499). The DCA revealed that the all-combined model illustrated the best overall net benefit in clinical application.ConclusionThe integrated model, combining multiparametric MRI-based radiomics, deep learning features, and clinical-radiological characteristics, may be utilized for the preoperative differentiation of USC from EEC.