AUTHOR=Liao Ruiheng , Xiao Yang , Chang Yujing , Zhang Zhang , Zhang Yange 

TITLE=Case report: Adolescent breast hypertrophy with a tendency toward phyllodes tumor formation: first reported case in China

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1652446

DOI=10.3389/fonc.2025.1652446

ISSN=2234-943X

ABSTRACT=Adolescent breast hypertrophy is a rare and persistent condition that affects peripubertal females both physiologically and psychologically. We present a case of a 14-year-old patient with bilateral giant breast enlargement who underwent a successful reduction mammoplasty of 16.5% Body Weight. The right breast exhibited focal interstitial proliferation myofibroblasts, suggesting a potential risk for phyllodes tumor development. This finding represents a novel histopathological association, unreported in the literature and first documented in China.