AUTHOR=Lin Huaitai , Yang Chanping , Zhu Jinhao , Yang Chenyu , Xu Zijian , Wu Zejin , Wang Xinjia , Wang Weidong 

TITLE=Metachronous multicentric giant cell tumor of bone treated with denosumab and mega-prosthesis revision: a rare case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 15 - 2025

YEAR=2025

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1651271

DOI=10.3389/fonc.2025.1651271

ISSN=2234-943X

ABSTRACT=IntroductionMulticentric giant cell tumor of bone is extremely rare, accounting for less than 1% of all giant cell tumor of bone (GCTB) cases. Metachronous multicentric GCTB is even rarer.Case presentationWe present a rare case of metachronous multicentric giant cell tumor of bone (GCTB) in a 27-year-old male, in whom three distinct lesions developed sequentially over a 10-year period: first in the right distal femur, followed by the proximal femur, and later the proximal tibia. To address progressive disease and prosthetic complications, the patient underwent revision of the mega-prosthesis combined with adjuvant denosumab therapy, followed by curettage of the subsequently emerging tibial lesion.ConclusionThis case illustrates the sequential development of multiple GCTB lesions and the importance of combined surgical reconstruction and denosumab therapy in long-term management.