Front. Oncol.Frontiers in OncologyFront. Oncol.2234-943XFrontiers Media S.A.10.3389/fonc.2025.1630154OncologyCorrectionCorrigendum: Rewired glycolysis by DTL accelerates oncometabolite L-lactate generation to promote breast cancer progressionLiuYuhao1†LiJinting2†CaoYiren2*LvMengzhu2*1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, China2Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Laboratory of Molecular Oncology, Peking University Cancer Hospital and Institute, Beijing, China
Edited and reviewed by: Juan Carlos Gallardo-Pérez, National Institute of Cardiology Ignacio Chavez, Mexico
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A Corrigendum on Rewired glycolysis by DTL accelerates oncometabolite L-lactate generation to promote breast cancer progression by Liu Y, Li J, Cao Y and Lv M (2025) Front. Oncol. 15:1583752. doi: 10.3389/fonc.2025.1583752DTLglycolysisL-lactatebreast cancerprogressionsection-in-acceptanceCancer Metabolism
In the published article, there was an error in Figure 6C as published. We regrettably discovered an inadvertent duplication of loading control bands (β-actin and GAPDH for CAL-51 cell line) between Figures 5A and Figure 6C during figure reorganization. We wish to emphasize that the duplicated controls originated from concurrent experiments — both Figures 5A and 6C datasets were generated during the same experimental batch, though logically separated into two figures to enhance manuscript readability. The corrected Figure 6C and its caption “Western blot analysis for the expression of stemness-associated genes in MDA-MB-231 and CAL-51 cells after DTL knockdown” appear below.
L-lactate supports cell proliferation and migration of breast cancer depending on DTL. (A) Volcano plot showing differentially expressed genes in breast cancer patients with low and high DTL expression. (B) Dot plot indicating the alternative signal pathways of KEGG enrichment analysis. (C) Western blot analysis for the expression of stemness-associated genes in MDA-MB-231 and CAL-51 cells after DTL knockdown. (D) Histogram showing the expression of indicated molecules after DTL knockdown in MDA-MB-231 and CAL-51 cells. (E) Immunoblotting analysis for the expression of stemness-related indicators in MDA-MB-231 and CAL-51 cells treated with different concentrations of L-lactate. (F) Histogram showing the levels of indicated molecules in MDA-MB-231 and CAL-51 cells treated with 5 mM L-lactate. (G) Histogram indicating the colony-forming efficiency of MDA-MB-231 and CAL-51 cells with 5 mM L-lactate treatment. (H) Histogram displaying the number of migrated breast cancer cells treated with 5 mM L-lactate. (I) Western blot analysis indicating the total L-lactylated levels of lysine in MDA-MB-231 and CAL-51 cells treated with 5 mM L-lactate. (J) Western blot analysis for the total L-lactylated levels of lysine in MDA-MB-231 and CAL-51 cells after DTL knockdown. Data in D, F, G and H were presented as mean ± S.D (n = 3). Two-tailed Student’s t-test.
A multi-panel scientific figure displaying various data related to gene expression and protein analysis: A) A volcano plot showing log fold changes of genes, highlighting 609 up-regulated and 359 down-regulated genes. B) A dot plot of gene set enrichment analysis, indicating pathways and gene ratios with color-coded p-values. C) Western blot images showing protein expression levels (ABCG2, SOX9, NANOG, SOX2, DTL, GAPDH) in MDA-MB-231 and CAL-51 cell lines with different siRNA treatments. D) Bar charts presenting fold differences in gene expression with siRNA treatment, including p-values. E) Western blot images for protein expression levels under varying lactate concentrations. F) Bar charts of fold differences in protein expression with lactate treatments in two cell lines, showing p-values. G) Bar chart of colony formation efficiency with different lactate treatments. H) Bar chart depicting the number of migrated cells under different lactate conditions, with corresponding p-values. I) Western blot images displaying Pan Kla protein levels with lactate treatment. J) Western blot images showing Pan Kla protein levels with siRNA treatments.
The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.
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