AUTHOR=Dang Ying , Du Aichao , Wei Wenyuan , Xue Jungang TITLE=Primary cervicothoracic melanoma of spinal cord: a case report and literature review JOURNAL=Frontiers in Oncology VOLUME=Volume 14 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1417268 DOI=10.3389/fonc.2024.1417268 ISSN=2234-943X ABSTRACT=A 53-year old male patient presented progressive numbness and weakness in the right limbs of 2year duration. Magnetic resonance imaging scans revealed an intramedullary lesion crossed over cervical and thoracic level accompanying with syringomyelia at the proximal end of the lesion. The patient underwent subtotal resection of the neoplasm. The histological findings of the tumor were consistent with an primary intramedullary malignant melanoma not initial ependymoma after careful dermatologic and ophthalmologic re-examination. Primary melanoma of the spinal cord, particularly cervicothoracic localization with syringomyelia, is seldomly reported in the literature.We report a case of this uncommon tumor and also discuss the clinical course, diagnosis, and treatment of it.