AUTHOR=Ji Yueru , Wan Zhuo , Yang Jian , Hao Miaowang , Liu Li , Qin Weiwei 

TITLE=The safety and efficacy of the re-administration of gilteritinib in a patient with FLT3-mutated R/R AML with CNS relapse: a case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1402970

DOI=10.3389/fonc.2024.1402970

ISSN=2234-943X

ABSTRACT=In this case report, we have reported that gilteritinib shows significant therapeutic effects on a R/R AML case remained refractory to prior treatment with sorafenib, multiple lines of intensive chemotherapy and HSCT. Experienced newly diagnosed AML 3 year ago and CNS relapse followed up for 23 months, the patient has sustained BM remission status with MRD negative after treated with gilteritinib. The positive anti-leukemic effect of gilteritinib may bring new hope for the treatment of FLT3 mutated AML with CNS relapse.