AUTHOR=Zhu Xiaonan , Feng Yaning , Fan Peiwen , Dong Danning , Yuan Jianlin , Chang Cheng , Wang Ruozheng 

TITLE=Increased co-expression of 4-1BB with PD-1 on CD8+ tumor-infiltrating lymphocytes is associated with improved prognosis and immunotherapy response in cervical cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 14 - 2024

YEAR=2024

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1381381

DOI=10.3389/fonc.2024.1381381

ISSN=2234-943X

ABSTRACT=The combination of agonistic antibodies with immune checkpoint inhibitors presents a promising avenue for cancer immunotherapy. Our objective is to explore the co-expression of 4-1BB, ICOS, CD28, with PD-1 on CD8+ T cells in the peripheral blood and tumor tissue of cervical cancer(CC) patients, with a specific focus on the association between the co-expression levels of 4-1BB with PD-1 and clinical features, prognosis as well as immunotherapy response. The goal is to offer valuable insights into cervical cancer immunotherapy.The combination of agonistic antibodies with immune checkpoint inhibitors is a promising cancer immunotherapy option.