AUTHOR=Qian Jing , Gracious Kaoma , Chen Li , Xu Song TITLE=Primary vaginal cancer after hysterectomy for benign conditions: a systematic review of the literature JOURNAL=Frontiers in Oncology VOLUME=Volume 14 - 2024 YEAR=2024 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2024.1334778 DOI=10.3389/fonc.2024.1334778 ISSN=2234-943X ABSTRACT=Background: Primary vaginal cancer is a rare condition. Some studies have revealed an increased risk of vaginal cancer among patients who have undergone hysterectomy for premalignant and malignant cervical disease.However, there is limited literature available on primary vaginal cancer following hysterectomy for benign conditions.Objectives: This review aimed to investigate available evidence on clinical characteristics, treatments, and outcomes of primary vaginal cancer following hysterectomy for benign diseases. Additionally, we provide a case of a patient who developed primary vaginal cancer 10 years after undergoing hysterectomy for abnormal uterine bleeding.