AUTHOR=Wang Wenliang , Jin Huaqing , Zhang Yan Dora , Yin Guosheng 

TITLE=Two-dimensional calibration-free odds design for phase I drug-combination trials

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1294258

DOI=10.3389/fonc.2023.1294258

ISSN=2234-943X

ABSTRACT=In oncology, it is commonplace to treat patients with a combination of drugs that deliver different effects from different disease-curing or cancer-elimination perspectives.Such drug combinations can often achieve higher efficacy in comparison with single-drug treatment due to synergy or non-overlapping toxicity. Due to the small sample size, there is a growing need for efficient designs for phase I clinical trials, especially for drugcombination trials. In the existing experimental design for phase I drug-combination trials, most of the proposed methods are parametric and model-based, either requiring