AUTHOR=Wang Zhen , Bai Jiayu , Liu Yujia , Li Peng , Jiao Guangyu 

TITLE=Risk factors for acute exacerbation of interstitial lung disease during chemotherapy for lung cancer: a systematic review and meta-analysis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1250688

DOI=10.3389/fonc.2023.1250688

ISSN=2234-943X

ABSTRACT=The aim of this study was to investigate the risk factors for acute exacerbation (AE) of interstitial lung disease caused by chemotherapy for lung cancer. Methods: We searched PubMed, Embase and The Cochrane Library databases from the establishment of each database to April 2023. Eligible studies were included, and the data of risk factors related to AE caused by chemotherapy in interstitial lung disease were extracted. Results: A total of 878 articles were retrieved, and 21 met the inclusion criteria. The studies included 1,275 patients with lung cancer combined with interstitial lung disease. The results of the meta-analysis showed four significant risk factors for AE of interstitial lung disease, namely age < 70 years (odds ratio [OR]: 1.98, 95% confidence interval [CI]: 1.05-3.72), forced vital capacity (FVC) (MD=-9.33, 95% CI: -13.7--4.97), usually interstitial pneumonia (UIP) pattern on computed tomography (CT) (OR: 2.11, 95% CI: 1.43-3.11), and serum surfactant protein D (SP-D) (SMD: 0.35, 95% CI: 0.03-0.67). Conclusion: When patients with lung cancer complicated with interstitial lung disease are aged < 70 years, have UIP pattern on CT, lower FVC value and higher serum levels of SP-D, chemotherapy should be carried out with care.