AUTHOR=Saijo Ken , Imai Hiroo , Ouchi Kota , Sasaki Keiju , Yoshida Yuya , Kawamura Yoshifumi , Taniguchi Sakura , Kasahara Yuki , Komine Keigo , Shirota Hidekazu , Takahashi Masanobu , Ishioka Chikashi 

TITLE=Depth of response may predict clinical outcome in patients with recurrent/metastatic head and neck cancer treated with pembrolizumab-containing regimens

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1230731

DOI=10.3389/fonc.2023.1230731

ISSN=2234-943X

ABSTRACT=Background: Pembrolizumab-containing regimens are standards of care for recurrent and metastatic head and neck squamous cell carcinoma (R/M HNSCC). The depth of response (DpR) predicts the survival of patients with several types of solid cancers; however, its association with the survival outcomes of patients with R/M HNSCC treated with pembrolizumab-containing regimens remains unclear.Methods: This study included 66 patients with R/M HNSCC who received a pemblolizumabcontaining regimen as a first-line therapy at