AUTHOR=Santoro Armando , Masini Silvia , Cavina Raffaele , Tronconi Maria Chiara , De Vincenzo Fabio 

TITLE=Rituximab in steroid-refractory immune-related pancreatitis: a case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1205720

DOI=10.3389/fonc.2023.1205720

ISSN=2234-943X

ABSTRACT=The use of immune checkpoint inhibitors (ICIs) for treating several types of cancers is increasing, but they may be associated with immune-related adverse events (irAEs). Pancreatitis is a rare irAE, mostly responsive to steroid treatment. There are no published data on the management of steroidrefractory ICI-induced pancreatitis. Rituximab has shown efficacy in the setting of relapsing non-ICIinduced autoimmune pancreatitis. However, its use has not been tested for treating immunotherapyrelated pancreatitis. Here, we present a case of a patient with steroid-refractory immune-related pancreatitis successfully treated with rituximab as a potential strategy for irAE management.