AUTHOR=Zhang Shuang , Cheng Ying 

TITLE=Immunotherapy for extensive-stage small-cell lung cancer: current landscape and future perspectives

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1142081

DOI=10.3389/fonc.2023.1142081

ISSN=2234-943X

ABSTRACT=Small-cell lung cancer (SCLC) is a fatal subtype of lung cancer characterized by high aggressive-ness, poor prognosis, and limited treatment options. For the first time in more than three decades, it has been demonstrated that the addition of immunotherapy to chemotherapy improved the survival of patients with extensive-stage SCLC, thereby establishing a new standard of first-line treatment. However, it is important to improve the curative effect of immunotherapy on SCLC and identify the patients who could benefit the most from such treatment. In this article, we re-view the current data, the development of novel immunotherapy strategies, and the discovery of potential predictive biomarkers of immunotherapy for SCLC.