AUTHOR=Wang Zuopeng , Yan Hanlei , Ma Yangyang , Yao Wei , Zheng Shan , Li Kai 

TITLE=Case Report: Kaposiform hemangioendothelioma with PIK3CA mutation successfully treated with sirolimus

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1132702

DOI=10.3389/fonc.2023.1132702

ISSN=2234-943X

ABSTRACT=Kaposiform hemangioendothelioma (KHE) is an extremely rare, locally aggressive vascular neoplasm. The etiopathogenesis of KHE was still poorly understood. In the present study, we found a new mutation in KHE(c.685delA, p.Thr229fs).The patient of KHE with PIK3CA mutation showed complete regression with sirolimus treatment. We proposed the inclusion of KHE with PIK3CA mutation may correlate with good response to sirolimus.