AUTHOR=Zhang Fang , Wang Yali , Li Hongjuan , Li Li , Yang Xiaofeng , You Xiaoyan , Tang Lina 

TITLE=Pan-cancer analysis identifies LIFR as a prognostic and immunological biomarker for uterine corpus endometrial carcinoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1118906

DOI=10.3389/fonc.2023.1118906

ISSN=2234-943X

ABSTRACT=Background
Leukemia inhibitory factor (LIF) exhibits significant tumor-promoting function of cancers, while its cognate receptor (LIFR) is considered as a tumor promotor or suppressor. The dysregulation of LIF and LIFR has been identified to be associated with the initiation, progression and metastasis for multiple cancer types. Although increasing studies revealed the indispensable critical role of LIFR in tumorigenesis for various cancers, there is no systematic analysis of LIFR yet.
Methods
In this research, we comprehensively analyzed the expression profile and prognostic values of LIFR and the correlation between LIFR with infiltration of immune cells and clinicopathological parameters across different tumor types using several bioinformatic tools. Moreover, we detected the effect of LIFR on Uterine Corpus Endometrial Carcinoma (UCEC) and evaluated the expression level of LIFR in clinical UCEC samples.
Results
We detected the aberrant expression of LIFR in cancers and its prognosis ability, especially in UCEC. Additionally, LIFR remarkably associated with immune infiltrating cells and checkpoint genes. Overexpression of LIFR suppressed the migration and invasion of UCEC cells in vitro. 
Conclusion
Our pan-cancer detection data provided a novel understanding of the roles of LIFR in oncogenesis in tumors.