On 26 June 2022, an advanced document retrieval was performed on the Web of Science Core Collection (WOSCC database). The publication date was limited from 1 January 2000 to 1 June 2022. The search formula was listed as follows:

#1 ((((((((TS=(Quality of Life)) OR TS=(Life Quality)) OR TS=(Health-Related Quality Of Life)) OR TS=(Health Related Quality Of Life)) OR TS=(HRQOL)) OR TS=(psychological impact)) OR TS=(emotional impact)) OR TS=(Psychological Wellbeing)) OR TS=(mental health)

#2((((((TS=(gynecology oncology)) OR TS=(gynecologic cancer)) OR TS=(gynecologic neoplasm)) OR TS=(cervical cancer)) OR TS=(ovarian cancer)) OR TS=(endometrial cancer)) OR TS=(gestational trophoblastic neoplasia)

Publication date 2000-01-01 – 2022-06-01

#1 AND #2

The detailed search process is outlined in Figure 1 . Articles and reviews were included in this bibliography analysis, and the language was restricted to English. Eventually, a total of 6,479 publications were selected and exported in plain text file format for full record and cited reference.

Bibliometrix R-package (http://www.bibliometrix.org) provides tools for quantitative bibliometrics and scientometrics research. It runs on RStudio v.4.1.2 software (RStudio, PBC, Boston, MA, USA). It can produce a descriptive analysis of a bibliographic data frame, as well as build a network for analyzing bibliographic coupling, co-citation, collaboration, and co-occurrence (22). We used it to extract the most relevant countries, journals, and locally cited publications as tables. RStudio was also used to conduct the geographic visualization analysis of country collaboration.

VOSviewer (version 1.6.18, the Centre for Science and Technology Studies at Leiden University (Netherlands)) is a software tool for the creation of maps based on network data and for visualizing and exploring these maps. VOSviewer can be used to construct networks of publications, journals, authors, research institutions, countries, keywords, or terms. With VOSviewer, bibliographic database files (such as Web of Science files) can be used to build a network. This software can be freely downloaded from www.vosviewer.com (20). In this analysis, we constructed a geographic map of countries and institutional networks based on the co-authorship links, and a publications network based on the citation links. The world borders of the geographic map were downloaded from https://www.tudelft.nl/en/librarv/research-analvtics/case-21-tu-delft-top-collaborators-2. Based on Clement Lev’s “Map of Countries” plugin for Gephi software, graph nodes are used to represent the country borders and their coordinates (23).

CiteSpace V6.1.R2 (Drexel University, Philadelphia, PA, United States) is a Java application for analyzing and visualizing co-citation networks (24). It can be freely downloaded from http://cluster.cis.drexel.edu/~cchen/citespace/download/. The new version 6.1.R2 was built on 20 June 2022. It can be used to build a cooperative network of authors, institutions, or countries; co-occurrence analysis of terms, keywords, or categories; co-citation analysis of references, authors, or journals; and coupling analysis of the paper (17). In this analysis, we use CiteSpace software to draw the dual-map overlay of journals, citation bursts of the top 20 reference and top 20 keywords, a network of authors, and the timeline view of the keywords. The parameter settings were set in the following: the timespan: 2000–2022 (Slice Length = 2), selection criteria: top 50 per slice, link retaining factor (LRF) = 3.0, look back years (LBY) = 5, e for top N (e) = 1.0.

GraphPad Prism 9.0 was used to draw the line graph of annual production and perform a linear regression based on this line graph. The coefficient of determination (R²) represents the proportion of variance in the dependent variable that can be predicted. The closer the R² value is to 1, the better the fitting; and the closer it is to 0, the worse the fitting.

In total, 6,479 publications were included in our study with the timespan from 2000 to 2022. There were 5,092 articles and 1,387 reviews, which account for 78.59% and 21.41%, respectively.

The number of published papers on the research of life quality or psychological impact of gynecology oncology patients is shown in Figure 2 . For the purpose of linear regression analysis, only publications from 2000 to 2021 are shown. In general, it has increased year by year. It can be seen that the rise slowed down in 2000–2003, while in recent years (2019–2021), the rise has been rapid, with an increase of about 50 papers per year.

The geographic visualization analysis of country collaboration based on the co-authorship analysis of VOSviewer and RStudio is shown in Figure 3 . To visualize clearly, only a minimum number of documents, not more than 20, were included in this map, which contained 38 countries. The top 10 most relevant countries according to the corresponding author’s country are listed in Table 1 . The listed countries published a total of 5,031 articles, accounting for 77.5% of the total. The United States ranked first (n = 2,075, 32.0%), followed by China (n = 572, 8.8%), the United Kingdom (n = 509, 7.9%), Australia (n = 342, 5.3%), Italy (n = 340, 5.2%), and so on. Table 1 also shows single-country publications (SCPs), multiple-country publications (MCPs), and MCP ratio (MCP/articles). France is the country with the highest MCP ratio (0.344), and Japan is the country with the lowest (0.052) in the top 10 list.

The institution network based on the co-authorship analysis is listed in Figure 4 .

In this network, only a minimum number of documents of not more than 10 were included, containing 390 organizations. The map shows the largest set of connected items consisting of 389 notes. It contains eight clusters.

The top 10 institutions that contributed to the publications are listed in Table 2 . As we can see, most top 10 affiliations came from the United States (n = 6) and one each from Australia, the United Kingdom, Canada, and the Netherlands. The University of Sydney contributes the most (n = 167) in this field, followed by Memorial Sloan Kettering Cancer Center (n = 166) and The University of Texas MD Anderson Cancer Center (n = 164). Memorial Sloan Kettering Cancer Center contributed the most citations (n = 8,399).

Figure 5 shows the dual-map overlay of journals, with the citing journal in which source articles were published on the left and the cited journal in which references were published on the right. Each spline curve started from a citing journal and pointed to a cited journal. Citing and cited journals are marked with ovals (25). Two green paths and one orange path are demonstrated as main citation paths through z-score analysis. The green paths present that the publications from the medicine/medical/clinical fields were most citing the health/nursing/medicine fields of journals (z = 9.13, f = 24,980) and the molecular/biology/genetics fields of journals (z = 4.98, f = 13,896). The orange path presents that the publications from the molecular/biology/genetics fields were most cited by the molecular/biology/immunology fields of journals (z = 1.67, f = 5042).

Table 3 lists the top 10 most relevant journals and most cited journals. Gynecologic Oncology contributed the highest publication numbers (n = 469). Among the top 10 relevant lists, the Journal of Clinical Oncology has the highest impact factor (IF = 50.769), and it also ranked first in the top 10 most cited journals (n = 18,100). The journal with the highest IF in the cited source list was the Lancet (IF = 202.731), followed by the New England Journal of Medicine (IF = 176.079) and JAMA-Journal of the American Medical Association (IF = 157.335). Moreover, it could be seen that four journals are in both the most relevant list and most cited list, namely, Gynecologic Oncology, Cancer, International Journal of Gynecological Cancer, and Journal of Clinical Oncology.

The citation of the document network is shown in Figure 6 . The network was based on the number of times they cited each other. There are 748 citations in this document, which meets our minimum requirement of 60. Finally, the largest set of connected items consisted of 496 items and 22 clusters. Table 4 lists the top 20 cited papers according to local citations. The global citation, which means the citation based on the Web of Science database, was also listed in Table 4 . The article (Global Cancer Statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries) written by Bray F et al. (26) in 2018 had the highest citation both locally (n = 149) and globally (n = 42,425). The top 12 had a local citation of more than 100 times.

The top 20 references with the strongest citation bursts are shown in Figure 7 . The basic meaning of burst detection is that the value of variable changes significantly in a short period of time. The reference with the strongest bursts was published by Bray F et al. in 2018 (strength = 71.11) followed by Siegel RL et al. in 2015 (strength = 35.84) and Ferlay J et al. in 2015 (strength = 30.69). Notably, the article written by Bray F et al. was also with the highest local and global citation numbers listed before. The citation bursts began in 2003 with Rebbeck TR et al. (from 2003 to 2007), Kauff ND et al. (from 2003 to 2007), and Rossouw JE et al. (from 2003 to 2007). The latest citation burst was detected in 2019 due to the article published by Bray F et al. (from 2019 to 2022).

The network of authors and the cluster by keywords are presented in Figure 8 . The modularity Q = 0.8285 (Q > 0.3 implies a reasonable clustering structure), and the weighted mean silhouette S = 0.9413 (S > 0.5 means reasonable clustering, and S > 0.7 implies convincing clustering). The largest cluster, #0, was tagged as uterine cervical neoplasms. It could be seen that authors Kim J and Lee J were in this cluster. Table 5 lists the top 10 relevant and most co-cited authors. Kim J was the most productive author with 63 publications, followed by Friedlander M (61 publications) and Lee J (55 publications). The author co-citation analysis of cited paper showed that Aaronson NK ranks first with a count of 426, followed by Siegel RL (356) and Jemal A (334).

A cluster of keywords was made by CiteSpace V software and presented as a timeline view of keywords ( Figure 9A ). The timeline view could make the newly emerged keywords be recognized easily. The red circle in this figure shows the citation bursts. The clusters were labeled by #0 genetic testing, #1 paclitaxel, #2 quality of life, #3 cervical cancer, and so on. Figure 9B shows the top 20 keywords with the strongest citation bursts. The “psychological impact” had the strongest bursts (strength = 37.03, 2002–2012), followed by “palliative care” (strength = 25.73, 2018–2022). The keywords “mortality” (2016–2022), “fertility preservation” (2016–2022), and “palliative care” (2018–2022) have bursts till 2022.