AUTHOR=Zang Bolun , Ding Luyue , Liu Linlin , Arun Kumar Senthil , Liu Wei , Zhou Chongchen , Duan Yongtao 

TITLE=The immunotherapy advancement targeting malignant blastomas in early childhood

JOURNAL=Frontiers in Oncology

VOLUME=Volume 13 - 2023

YEAR=2023

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2023.1015115

DOI=10.3389/fonc.2023.1015115

ISSN=2234-943X

ABSTRACT=Malignant blastomas develop chronologically in all functional body organs inflicting severe health ailments in younger children. Malignant blastomas exhibit diverse clinical characteristics in compliance with their emergence in the functional body organs. Surprisingly, neither of these preferred treatment types: surgery nor radiotherapy, and chemotherapy witnessed promising or effective to treat malignant blastomas among younger child patients. In recent times, the invention of innovative immunotherapeutic procedures encompassing monoclonal antibodies, and chimeric-antigen based receptor (CAR) cell therapy coupled with the clinical exploration of reliable therapeutic targets and immune regulatory pathways targeting malignant blastomas, procures wide attention amongst the clinicians of this era.