AUTHOR=Lim-Fat Mary Jane , Macdonald Maria , Lapointe Sarah , Climans Seth Andrew , Cacciotti Chantel , Chahal Manik , Perreault Sebastien , Tsang Derek S. , Gao Andrew , Yip Stephen , Keith Julia , Bennett Julie , Ramaswamy Vijay , Detsky Jay , Tabori Uri , Das Sunit , Hawkins Cynthia 

TITLE=Molecular testing for adolescent and young adult central nervous system tumors: A Canadian guideline

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.960509

DOI=10.3389/fonc.2022.960509

ISSN=2234-943X

ABSTRACT=The 2021 World Health Organization (WHO) classification of CNS tumors incorporates molecular signatures with histology and has highlighted differences across pediatric vs adult-type CNS tumors. However, adolescent and young adults (AYA; aged 15–39), can suffer from tumors across this spectrum and is a recognized orphan population that requires multidisciplinary, specialized care, and often through a transition phase. To advocate for a uniform testing strategy in AYAs, pediatric and adult specialists from neuro-oncology, radiation oncology, neuropathology, and neurosurgery helped develop this review and testing framework through the Canadian AYA Neuro-Oncology Consortium. We propose a comprehensive approach to molecular testing in this unique population, based on the recent tumor classification and within the clinical framework of the provincial health care systems in Canada.