AUTHOR=Du Zefan , Li Tianwen , Huang Junbin , Chen Yun , Chen Chun 

TITLE=Arginase: Mechanisms and Clinical Application in Hematologic Malignancy

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.905893

DOI=10.3389/fonc.2022.905893

ISSN=2234-943X

ABSTRACT=Compared to normal tissues and cells, the metabolic patterns of tumor illnesses are more complex, and there are hallmarks of metabolic reprogramming in energy metabolism, lipid metabolism, and amino acid metabolism. When tumor cells are in a state of fast growth, they are susceptible to food shortage, resulting in growth suppression. Using this metabolic sensitivity of tumor cells to construct amino acid consumption therapy does not harm the function of normal cells, which is the focus of metabolic therapy research at the moment. As a non-essential amino acid, arginine is involved in numerous crucial biological processes, including the signaling system, cell proliferation, and material metabolism. Rapidly dividing tumor cells are more likely to be deficient in arginine; hence, utilizing arginine enzyme to consume arginine can suppress tumor growth. Due to the absence of arginine succinate synthase, arginine succinate lyase, and ornithine carbamoyl transferase in some blood tumors, arginine enzymes may be employed to treat blood tumors. By investigating the mechanism of arginine enzyme treatment and the mechanism of drug resistance in greater depth, arginine enzyme treatment becomes more successful in hematological cancers and a new anti-cancer agent in clinical practice.