AUTHOR=Huimin Zhou , Xueting Wang , Qi Qi , Lingxin Feng , Xue Yang , Zhuang Yu , Jing Wang 

TITLE=Multiple Primary Lung Cancers With ALK Rearrangement: A Case Report and Literature Review

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.897451

DOI=10.3389/fonc.2022.897451

ISSN=2234-943X

ABSTRACT=Multiple primary lung cancers (MPLC) is that patients with lung cancer may present with two primaries at the same time (synchronous multiple primary lung cancer, SMPLC) or may develop a second, metachronous primary lung cancer after treatment of the initial lesion. Currently there are no unambiguous guidelines available for the diagnosis and treatment of MPLCs. Herein, we report a case of double primary lung cancers with ALK rearrangement. The patient was treated with chemotherapy, targeted therapy, radiotherapy. The patient is free of locally recurrent or distant disease at 2 years.