AUTHOR=Nastasi Nicoletta , Bruno Gennaro , Favre Claudio , Calvani Maura 

TITLE=Role of β3-Adrenergic Receptor in Bone Marrow Transplant as Therapeutical Support in Cancer

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.889634

DOI=10.3389/fonc.2022.889634

ISSN=2234-943X

ABSTRACT=β3-adrenergic receptor (β3-AR) is the last β-adrenoceptor subtype identified. β3-AR is widely expressed and regulates numerous physiological processes and it is also a potential target in the treatment of many diseases, including cancers. For some type of cancers, bone marrow transplant (BMT) represents a valid therapeutic support, especially in case of necessity of high-dose chemotherapy and radiotherapy. For a successful BMT it is necessary that donor’s hematopoietic stem cells (HSCs) correctly reach the staminal niche in the recipient’s bone marrow (BM) and contribute to restore normal hematopoiesis in order to rapidly repopulate BM and provide all the healthy blood cells of which the patient need. Generally, it takes a long time. Control and accelerate homing and engraftment of HSCs could represent a helpful approach to avoid complications and undesirable effects of BMT. The evidence that β-adrenergic system has a role in the BM can be found in different studies and this leads us to hypothesize that studying this field could be interesting to meliorate the most critical aspects of a BMT. Here, we collected data present in literature about the role of β3-AR in the BM with the purpose of discover a possible utility of β3-AR modulation in regulating hematopoietic stem cells trafficking and hematopoiesis.