Front. Oncol. Frontiers in Oncology Front. Oncol. 2234-943X Frontiers Media S.A. 10.3389/fonc.2022.857062 Oncology Original Research The Effect of Complications on Oncological Outcomes of Colorectal Cancer Patients After Primary Surgery: A Propensity Score Matching Analysis Liu Xiao-Yu 1 † Zhang Bin 1 † Kang Bing 2 Cheng Yu-Xi 1 Yuan Chao 1 Tao Wei 1 Wei Zheng-Qiang 1 Peng Dong 1 * 1 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China 2 Department of Clinical Nutrition, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Edited by: Annamaria Auricchio, University of Campania Luigi Vanvitelli, Italy

Reviewed by: Marco Massani, ULSS2 Marca Trevigiana, Italy; Michele Manigrasso, University of Naples Federico II, Italy

*Correspondence: Dong Peng, carry_dong@126.com

This article was submitted to Surgical Oncology, a section of the journal Frontiers in Oncology

†These authors share first authorship

 03 06 2022 2022 12 857062 18 01 2022 04 05 2022 Copyright © 2022 Liu, Zhang, Kang, Cheng, Yuan, Tao, Wei and Peng 2022 Liu, Zhang, Kang, Cheng, Yuan, Tao, Wei and Peng

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

 Purpose

The purpose of this study is to explore the oncologic outcomes of complications on colorectal cancer (CRC) patients who underwent primary surgery using a propensity score matching (PSM) analysis.

 Methods

A retrospective study was conducted from Jan 2011 to Jan 2020 in a clinical center. The overall survival (OS) and disease-free survival (DFS) were compared among the no complications group, the major complications group and the minor complications group.

 Results

A total of 4250 CRC patients who underwent radical primary surgery were included in the current study. Among them, 927 (21.8%) patients suffered complications. After 1:1 ratio PSM, there were 98 patients in the major complications group and in the minor complications group, and 911 patients in the overall complications group and in the no complications group. There was no significant difference in terms of baseline information after PSM (p>0.05). Complications were independent predictors of OS (p=0.000, HR=1.693, 95% CI=1.476-1.941) and DFS (p=0.000, HR=1.555, 95% CI=1.367-1.768). In terms of specific tumor stage, the no complications group had better OS on all stages (p=0.006) and stage III (p=0.003) CRC than the complications group after PSM. Furthermore, the no complications group had better DFS on all stages (p=0.005) and stage III (p=0.021) CRC than the complications group after PSM. However, there was no significant difference between the minor complications group and the major complications group in different tumor stages (p>0.05).

 Conclusion

Complications were associated with poor prognosis of CRC and surgeons should be cautious of the adverse events.

 colorectal cancer outcome complications propensity score matching surgery Introduction

Colorectal cancer (CRC) is one of the most common cancers in the world (1). There were an estimated 1.09 million new cases in 2018 which accounted for 10% of all cancer cases (2). Although there were many treatments for CRC, radical resection was still the cornerstone (3–5).

Despite the experienced surgical technique, the implementation of modern perioperative programs and the improvement of surgical instruments, the incidence of complications is still high (6–8). Complications can increase hospital stay and costs (9). As was reported in previous studies, complications could affect the prognosis of digest cancers including esophageal cancer and gastric cancer (10, 11).

However, the effect of complications on CRC patients remained controversial. Most studies reported that complications were associated with poor prognosis (12–14), but few studies reported that complications had no impact on prognosis (15, 16). Therefore, the purpose of this study is to explore the oncologic outcomes of complications on CRC patients who underwent primary surgery.

 Methods

A retrospective study was conducted from Jan 2011 to Jan 2020 in a single clinical center. This study was in accordance with the World Medical Association Declaration of Helsinki. Ethical approval was obtained from the Institutional Ethics Committee of the First Affiliated Hospital of Chongqing Medical University (2021-537), and all patients signed informed consents.

Patient`s Selection

Patients who underwent primary CRC surgery and confirmed by pathology were included in this study (n=5473). The exclusion criteria were as follows: 1, incomplete perioperative medical information (n=323); 2, stage IV CRC (n=875); and 3, Non-R0 CRC surgery (n=25). Finally, 4250 CRC patients were identified from the database of a single clinical center and the flow chart was shown in Figure 1 .

Flow chart of patient selection.

 Surgery Management

We performed radical CRC surgery which was according to the principles of oncology. Total mesorectal excision or complete mesocolic excision was performed, and the pathology confirmed R0 resection. The American Joint Committee on Cancer suggested a minimum of 12 lymph nodes to be assessed in the surgical specimen to verify lymph-node negative disease (17). Patients were regularly followed-up every three months for the first three years and six months for the following two years.

 Definition

The tumor stage was diagnosed according to the AJCC 8th Edition (18). Complications were defined according to the Clavien-Dindo classification (19), major complications were defined as ≥ III classification complications and minor complications were defined as I or II classification complications. Overall survival (OS) was defined as the time from radical CRC surgery to the time of death, last follow-up or lost follow-up. Disease-free survival (DFS) was defined as the time from radical CRC surgery to the time of recurrence, death, last follow-up or lost follow-up.

 Data Collection

We collected the medical information from the inpatient system, outpatient system and through telephone reviews. The baseline information which included age, sex, body mass index (BMI), patients’ habit (smoking and drinking), comorbidity (coronary heart disease (CHD), type 2 diabetes mellitus (T2DM) and hypertension), surgery history, neoadjuvant therapy, surgical methods, protective stoma, tumor location and tumor stage were collected.

 Propensity Score Matching (PSM)

PSM was conducted between the complications group and the no complications group, and between the major complications group and the minor complications group. Nearest neighbor matching was performed without replacement at a 1:1 ratio and a caliper width with a 0.01 standard deviation was specified. The following baseline information were matched:age, sex, BMI, smoking, drinking, surgery history, hypertension, T2DM, CHD, neoadjuvant therapy, surgical methods, protective stoma, tumor location and tumor stage.

 Statistical Analysis

Continuous variables are expressed as the mean ± SD and independent-sample t test was used to analyze the difference between the complications group and the no complications group, and between the major complications group and the minor complications group. Frequency variables are expressed as n (%), and Chi-square test was used. The Kaplan-Meier curve was conducted to compare no complications/overall complications/major complications/minor complications on different tumor stages, and cox regression analyses were performed to identify independent predictive factors for OS and DFS. Data were analyzed using SPSS (version 22.0) statistical software. A bilateral p value of <0.05 was considered statistically significant.

 Results Patients

A total of 4250 CRC patients who underwent radical primary surgery were included in the current study. Among them, 927 (21.8%) patients suffered complications. PSM was conducted between the complications group and the no complications group, and between the major complications group and the minor complications group. After 1:1 ratio PSM, there were 98 patients in the major complications group and in the minor complications group, and 911 patients in the overall complications group and in the no complications group ( Figure 1 ).

 Baseline Characteristics of Included Patients Before and After PSM

Baseline information were compared between the complications group and the no complications group. The complications group had older age (p=0.000), higher rate of smoking (p=0.042), surgery history (p=0.002), hypertension (p=0.000), T2DM (p=0.000) and CHD (p=0.000), and lower rate of laparoscopic CRC surgery (p=0.000) and neoadjuvant therapy (p=0.006) before PSM. After 1:1 ratio PSM, there were no significant difference between the complications group and the no complications group (p>0.05) in terms of baseline information ( Table 1 ).

Baseline characteristics of included patients before and after PSM.

Characteristics Before PSM After PSM
Complications (927) No complications (3323) P value Complications (911) No complications (911) P value
Age (year) 65.6 ± 12.5 62.2 ± 11.9 0.000* 65.3 ± 12.5 65.3 ± 11.4 0.925
Sex 0.140 0.630
 Male 564 (60.8%) 1932 (58.1%) 554 (60.8%) 564 (61.9%)
 Female 363 (39.2%) 1391 (41.9%) 357 (39.2%) 347 (38.1%)
BMI (kg/m2) 22.5 ± 3.4 22.7 ± 3.2 0.052 22.5 ± 3.3 22.4 ± 3.2 0.433
Smoking 377 (40.7%) 1230 (37.0%) 0.042* 369 (40.5%) 375 (41.2%) 0.775
Drinking 289 (31.2%) 638 (19.2%) 0.673 283 (31.1%) 283 (31.1%) 1.000
Surgery history 252 (27.2%) 743 (22.4%) 0.002* 240 (26.3%) 236 (25.9%) 0.831
Hypertension 290 (31.3%) 818 (24.6%) 0.000* 278 (30.5%) 260 (28.5%) 0.355
T2DM 149 (16.1%) 372 (11.2%) 0.000* 138 (15.1%) 152 (16.7%) 0.370
CHD 59 (6.4%) 120 (3.6%) 0.000* 55 (6.0%) 49 (5.4%) 0.545
Neoadjuvant therapy 34 (3.7%) 199 (6.0%) 0.006* 34 (3.7%) 36 (4.0%) 0.807
Protective stoma 39 (4.2%) 180 (5.4%) 0.141 39 (4.3%) 32 (3.5%) 0.397
Laparoscopy 700 (75.5%) 2908 (87.5%) 0.000* 699 (76.7%) 701 (76.9%) 0.912
Tumor location 0.373 0.707
 Colon 416 (44.9%) 1546 (46.5%) 409 (44.9%) 417 (45.8%)
 Rectum 511 (55.1%) 1777 (53.5%) 502 (55.1%) 494 (54.2%)
Tumor stage 0.303 0.398
 I 193 (20.8%) 657 (19.8%) 190 (20.9%) 176 (19.3%)
 II 379 (40.9%) 1453 (43.7%) 369 (40.5%) 397 (43.6%)
 III 355 (38.3%) 1213 (36.5%) 352 (38.6%) 338 (37.1%)

Variables are expressed as the mean ± SD, n (%), *P-value <0.05.

T2DM, type 2 diabetes mellitus; BMI, body mass index; PSM, propensity score matching; CHD, coronary heart disease.

 Baseline Characteristics of Complications Before and After PSM

We compared baseline information between the major complications group and the minor complications group. The major complications group had higher portion of males (p=0.005), drinking (p=0.020) and rectal cancer (p=0.001) before PSM. After 1:1 ratio PSM, no significant difference was found in the two groups (p>0.05) ( Table 2 ).

Baseline characteristics of complications before and after PSM.

Characteristics Before PSM After PSM
Major complications (99) Minor complications (828) P value Major complications (98) Minor complications (98) P value
Age (year) 67.0 ± 11.4 65.4 ± 12.6 0.243 66.8 ± 11.4 66.3 ± 12.3 0.754
Sex 0.005* 0.621
 Male 73 (73.7%) 491 (59.3%) 72 (73.5%) 75 (76.5%)
 Female 26 (26.3%) 337 (40.7%) 26 (26.5%) 23 (23.5%)
BMI (kg/m2) 22.8 ± 3.5 22.5 ± 3.3 0.361 22.8 ± 3.5 23.6 ± 3.3 0.105
Smoking 47 (47.5%) 330 (39.9%) 0.145 47 (48.0%) 41 (41.8%) 0.389
Drinking 41 (41.4%) 248 (30.0%) 0.020* 40 (40.8%) 36 (36.7%) 0.558
Surgery history 23 (23.2%) 229 (27.7%) 0.350 23 (23.5%) 24 (24.5%) 0.867
Hypertension 31 (31.3%) 259 (31.3%) 0.995 31 (31.6%) 33 (33.7%) 0.761
T2DM 17 (17.2%) 132 (15.9%) 0.753 17 (17.3%) 23 (23.5%) 0.288
CHD 7 (7.1%) 52 (6.3%) 0.761 7 (7.1%) 13 (13.3%) 0.157
Neoadjuvant therapy 3 (3.0%) 31 (3.7%) 1.000 3 (3.1%) 4 (4.1%) 1.000
Protective stoma 3 (3.0%) 36 (4.3%) 0.790 3 (3.1%) 1 (1.0%) 0.621
Laparoscopy 78 (78.8%) 622 (75.1%) 0.423 77 (78.6%) 78 (79.6%) 0.861
Tumor location 0.001* 0.227
 Colon 29 (29.3%) 387 (46.7%) 29 (29.6%) 37 (37.8%)
 Rectum 70 (70.7%) 441 (53.3%) 69 (70.4%) 61 (62.2%)
Tumor stage 0.078 0.936
 I 29 (29.3%) 164 (19.8%) 28 (28.6%) 26 (26.6%)
 II 34 (34.3%) 345 (41.7%) 34 (34.7%) 36 (36.7%)
 III 36 (36.4%) 319 (38.5%) 36 (36.7%) 36 (36.7%)

Variables are expressed as the mean ± SD, n (%), *P-value <0.05.

T2DM, type 2 diabetes mellitus; BMI, body mass index; PSM, propensity score matching; CHD, coronary heart disease.

 Univariate and Multivariate Analysis of OS and DFS

The medium follow-up time was 31 (1-113) months. Univariate analysis was conducted to find potential factors for prognosis and multivariate analysis was conducted to identify the independent predictors for prognosis.

The Kaplan-Meier curve was conducted to compare no complications/overall complications/major complications/minor complications. The no complications group had better OS (p=0.000) and DFS (p=0.000) than the minor complications group and the major complications group ( Figure 2 ).

Prognosis among different complications groups. (A), OS; (B), DFS. OS, overall survival; DFS, disease-free survival.

In terms of OS, age (p=0.000, HR=1.936, 95% CI=1.661-2.321), tumor stage (p=0.000, HR=2.088, 95% CI=1.844-2.364) and complications (p=0.000, HR=1.693, 95% CI=1.476-1.941) were independent predictors ( Table 3 ).

Univariate and multivariate analysis of overall survival.

Risk factors Univariate analysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Age (>/≤64, years) 2.141 (1.817-2.522) 0.000* 1.963 (1.661-2.321) 0.000*
Sex (male/female) 0.897 (0.763-1.055) 0.188
BMI (>/≤22.6) 0.793 (0.675-0.930) 0.004* 0.878 (0.747-1.032) 0.114
Hypertension (yes/no) 1.047 (0.874-1.255) 0.618
T2DM (yes/no) 1.267 (1.005-1.598) 0.045* 1.055 (0.834-1.334) 0.657
Tumor site (colon/ rectum) 1.160 (0.990-1.359) 0.067
Tumor stage (III/II/I) 2.073 (1.831-2.346) 0.000* 2.088 (1.844-2.364) 0.000*
Smoking (yes/no) 1.075 (0.914-1.264) 0.382
Drinking (yes/no) 1.040 (0.876-1.234) 0.654
CHD (yes/no) 1.299 (0.889-1.898) 0.177
Complications (major/minor/none) 1.749 (1.530-1.999) 0.000* 1.693 (1.476-1.941) 0.000*

*P-value <0.05.

HR, Hazard ratio; CI, confidence interval; BMI, body mass index; T2DM, type 2 diabetes mellitus; CHD, coronary heart disease.

AS for DFS, age (p=0.000, HR=1.728, 95% CI=1.489-2.006), tumor stage (p=0.000, HR=2.047, 95% CI=1.830-2.291) and complications (p=0.000, HR=1.555, 95% CI=1.367-1.768) were independent predictors as well ( Table 4 ).

Univariate and multivariate analysis of disease-free survival.

Risk factors Univariate analysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Age (>/≤64, years) 1.852 (1.598-2.146) 0.000* 1.728 (1.489-2.006) 0.000*
Sex (male/female) 0.902 (0.778-1.046) 0.172
BMI (>/≤22.6) 0.854 (0.739-0.988) 0.034* 0.938 (0.810-1.085) 0.387
Hypertension (yes/no) 1.038 (0.880-1.224) 0.659
T2DM (yes/no) 1.136 (0.914-1.412) 0.252
Tumor site (colon/ rectum) 1.085 (0.939-1.254) 0.268
Tumor stage (III/II/I) 2.039 (1.823-2.282) 0.000* 2.047 (1.830-2.291) 0.000*
Smoking (yes/no) 1.085 (0.936-1.257) 0.279
Drinking (yes/no) 1.036 (0.886-1.211) 0.661
CHD (yes/no) 1.228 (0.866-1.741) 0.250
Overall complications (major/minor/none) 1.599 (1.410-1.814) 0.000* 1.555 (1.367-1.768) 0.000*

*P-value <0.05.

HR, Hazard ratio; CI, confidence interval; BMI, body mass index; T2DM, type 2 diabetes mellitus; CHD, coronary heart disease.

 Survival Analysis on Different Tumor Stages After PSM

The no complications group had better OS on all stages (p=0.006) and stage III (p=0.003) CRC than the complications group after PSM ( Figure 3 ). Furthermore, the no complications group had better DFS on all stages (p=0.005) and stage III (p=0.021) CRC than the complications group after PSM ( Figure 4 ).

OS between the no complications group and the overall complications group after PSM. (A), all stages; (B), stage I; (C), stage II; (D), stage III. OS, overall survival; PSM, propensity score matching.

DFS between the no complications group and the overall complications group after PSM. (A), all stages; (B), stage I; (C), stage II; (D), stage III. DFS, disease-free survival; PSM, propensity score matching.

However, there was no significant difference between the minor complications group and the major complications group in terms of all stages, stage I, stage II or stage III (p>0.05) ( Figures 5 , 6 ).

OS between the major complications group and the minor complications group after PSM. (A), all stages; (B), stage I; (C), stage II; (D), stage III. OS, overall survival; PSM, propensity score matching.

DFS between the major complications group and the minor complications group after PSM. (A), all stages; (B), stage I; (C), stage II; (D), stage III. DFS, disease-free survival; PSM, propensity score matching.

 Discussion

In this study, complications were independent predictors of OS and DFS. In terms of specific tumor stage, the no complications group had better OS on all stages and stage III CRC than the complications group after PSM. Furthermore, the no complications group had better DFS on all stages, and stage III CRC than the complications group after PSM. However, there was no significant difference between the minor complications group and the major complications group in different stages.

After CRC surgery, the incidence of complications was 18%-38% (6–8, 20–22). Complications could increase hospital stay and costs (9), furthermore, patients’ mental stress would increase, and some complications might be life-threatening. Therefore, surgeons should be cautious of complications and careful perioperative management was needed.

According to the Clavien-Dindo classification (19), complications could be divided into minor complications and major complications. Minor complications required observation, infusion and blood transfusion, and major complication required surgery, endoscopy or intervention. Various factors could result in complications including blood transfusion, T2DM and operation time (23, 24), moreover, complications could affect the prognosis (12–14).

Nowakowski M et al. (13) analyzed 265 CRC patients for three years and found that complications after laparoscopic CRC surgery had an impact on survival. Similarly, Slankamenac K et al. (14) reported that complications were associated with poorer long-term survival after surgery for CRC. However, Galata C et al. (15) found that neither overall complications nor major surgical complications were risk factors for decreased survival. The specific role of minor complications and major complications was not analyzed in previous studies. Furthermore, the PSM method was used to match the baseline information, which could minimize the selection bias. Besides, only one study reported the effect of complications on CRC using PSM (12), however, the included number of CRC patients was relatively small, and the specific role of minor complications and major complications was lacking in that PSM study.

To our knowledge, this is the first study to analyze the specific role of minor complications and major complications on different tumor stages of CRC using PSM.

There were many factors which could result in poor prognosis of CRC patients including tumor stage, age, BMI and T2DM (25–27). In the current study, we found that age, tumor stage and complications were independent factors of OS and DFS as well. The mechanism of complications which worsened the prognosis might be as follows: 1, complications might delay the follow-up chemotherapy of CRC patients, thus affecting OS and DFS (28, 29); 2, complications directly caused damage to the patients’ organs and inhibition of the adaptive immune response, resulting in malfunction, thus affecting OS and DFS (8, 30); and 3, postoperative peritoneal infection enhanced the invasive activity of residual tumor cells after CRC surgery (31).

In terms of specific CRC tumor stage, we found that OS was worse in stage III CRC patients, however, OS was not affected in stage I and II CRC. The mechanism was unclear, but stage III CRC patients might be more fragile to the delay of chemotherapy after CRC surgery.

This study had some limitations. First, this was a single-center retrospective study. Second, the follow-up time was relatively short in this study which might lead to inaccuracy of the outcomes. Therefore, multi-center, large-sample studies are needed in the following studies to clarify the exact relationship between complications and prognosis.

In conclusion, complications were associated with poor prognosis of CRC and surgeons should be cautious of the adverse events.

 Data Availability Statement

The datasets used and analyzed during the current study are available from the corresponding author on reasonable request.

 Ethics Statement

Ethical approval was obtained from the Institutional Ethics Committee of the First Affiliated Hospital of Chongqing Medical University (2021-537), and all patients signed informed consents. The patients/participants provided their written informed consent to participate in this study.

 Author Contributions

All authors contributed to data collection, BK and DP contributed to the data analysis; DP led the quality assessments; X-YL and BZ write the origin draft; Y-XC, CY, WT, and Z-QW revised the manuscript. All the authors have agreed on the manuscript which will be submitted, gave final approval of the version to be published, and agree to be accountable for all aspects of the work.

 Funding

This study was supported by Chongqing key diseases Research and Application Demonstration Program (Colorectal Cancer Prevention and Treatment Technology Research and Application Demonstration [No. 2019ZX003]).

 Conflict of Interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

 Publisher’s Note

All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.

 Acknowledgments

We thank all the authors whose publications are referred in our article.

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