AUTHOR=Lu Chang , Zhang Yi-Chen , Chen Zhi-Hong , Zhou Qing , Wu Yi-Long 

TITLE=Applications of Circulating Tumor DNA in Immune Checkpoint Inhibition: Emerging Roles and Future Perspectives

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.836891

DOI=10.3389/fonc.2022.836891

ISSN=2234-943X

ABSTRACT=Immune checkpoint inhibitors (ICIs), especially anti-PD-1/PD-L1 antibodies, have made dramatic progress in treatment of lung cancer, especially for non-oncogene driven patients. However, responses are limited to a subset of patients, and which subset of patients will benefit from ICI remains unknown. With the advantage of minimally invasive, dynamic monitoring, non-invasive biomarkers appear as promising candidates to predicting response, monitoring resistance and tracking evolution of lung cancer during ICIs treatment. In the present review, we summarize predictive non-invasive biomarkers. We examine the potential of pre- and on-treatment features, alongside multiparameter models integrating non-invasive biomarkers of ICIs. We further discuss roles of liquid biopsies in monitoring treatment resistance, as well as challenges in clinical translation.