AUTHOR=Chen Kuo , Zhang Jin , Beeraka Narasimha M. , Tang Chengyun , Babayeva Yulia V. , Sinelnikov Mikhail Y. , Zhang Xinliang , Zhang Jiacheng , Liu Junqi , Reshetov Igor V. , Sukocheva Olga A. , Lu Pengwei , Fan Ruitai 

TITLE=Advances in the Prevention and Treatment of Obesity-Driven Effects in Breast Cancers

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.820968

DOI=10.3389/fonc.2022.820968

ISSN=2234-943X

ABSTRACT=Obesity and associated chronic inflammation were shown to facilitate breast cancer (BC) growth and metastasis. Leptin, adiponectin, estrogens, and several pro-inflammatory cytokines are involved in development of obesity-driven BCs through the activation of multiple oncogenic and pro-inflammatory pathways. The aim of this study was to assess the reported mechanisms of obesity-induced breast carcinogenesis and effectiveness of conventional & complementary BC therapies. We screened published original articles, reviews and meta-analyses that addressed the involvement of obesity-related signaling mechanisms in the BC development, BC treatment/prevention approaches, and post-treatment complications. PubMed, Medline, eMedicine, National Library of Medicine (NLM), and ReleMed databases were used to retrieve relevant studies using a set of keywords, including ‘obesity’, ‘oncogenic signaling pathways’, ‘inflammation’, ‘surgery’, ‘radiotherapy’, ‘conventional therapies’, and ‘diet’. Multiple studies indicated that effective BC treatment requires involvement of diet and exercise-based approaches in obese postmenopausal women. Furthermore, active lifestyle and diet-related interventions improved the patients’ overall quality of life and minimized adverse side effects after traditional BC treatment, including postsurgical lymphedema, post-chemo nausea, vomiting, and fatigue. Further investigation of beneficial effects of diet and physical activity may help to improve obesity-linked cancer therapies.