AUTHOR=Lv Wenjie , Zheng Dawen , Guan Wenbin , Wu Ping TITLE=Axillary lymph node dissection combined with radiotherapy for trichilemmal carcinoma with giant lymph node metastasis: A case report JOURNAL=Frontiers in Oncology VOLUME=Volume 12 - 2022 YEAR=2022 URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1019140 DOI=10.3389/fonc.2022.1019140 ISSN=2234-943X ABSTRACT=Background: Trichilemmal carcinoma (TC) is a rare malignancy with a poor outcome if local recurrence and distant metastasis occur. There is no treatment strategy for such a disease. Case presentation: We reported a complicated case of TC in right lower abdomen with ipsilateral axillary and inguinal lymph node metastases. After surgery and radiotherapy, there was no recurrence or metastasis on the follow-up to date. Conclusion: We believe that even considered as a tumor of low malignant potential, TC still has the risk of recurrence and metastasis, and the lymph node status should be identified if a high suspicion or diagnosis is made. Regional lymph node dissection followed by local radiotherapy is recommended as the optimal treatment strategy for patients with lymph node metastasis of TC. Screening for metastasis and close follow-up are indispensable for improving prognosis.