AUTHOR=Restaino Stefano , Paparcura Federico , Giorgiutti Cristina , Trojan Diletta , Montagner Giulia , Pengo Giancarlo , Pividore Grazia , Albanese Roberta , Rampino Emanuele , Dogareschi Teresa , Bove Tiziana , Titone Francesca , Trovò Marco , Garganese Giorgia , Parodi Pier Camillo , Scambia Giovanni , Driul Lorenza , Vizzielli Giuseppe 

TITLE=Human amniotic membrane for myocutaneous dehiscence after a radical surgical treatment of vulvar cancer: A case report

JOURNAL=Frontiers in Oncology

VOLUME=Volume 12 - 2022

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2022.1009884

DOI=10.3389/fonc.2022.1009884

ISSN=2234-943X

ABSTRACT=Backgroud: the application of the amniotic membrane could have a favourable effect on tissue repair and regeneration. We report the first case of implant of an amniotic membrane in a patient affected by myo-cutaneous dehiscence, after a radical surgical treatment for vulvar cancer. 
Methods: 74-year-old patient affected by vulvar cancer. After radiotherapy, the patient underwent to an anterior pelvic exenteration with uretero-ileo-cutaneostomy by Wallace, bilateral pelvic lymphadenectomy, omental biopsies, omental flap, bilateral inguinal lymphadenectomy, resection of ulcerated left inguinal lesion, reconstruction with left gracilis muscle flap and locoregional V-Y advancement flap. The patient developed a myo-cutaneous dehiscence. Two months after the surgery, following an accurate curettage of the wound and negative pressure therapy, a patch of human amniotic membrane was implanted. 
Results: the surgical procedure was easy, feasible and did not require long operating room times. No intraoperative or postoperative complications occurred. The results obtained were encouraging with a marked improvement in the surgical wound.
Conclusion: the use of amniotic membranes was safely and easily performed to promote the healing of complicated surgical wounds.