AUTHOR=Shen Ziyuan , Zhang Shuo , Zhang Meng , Hu Lingling , Sun Qian , He Chenlu , Yan Dongmei , Ye Jingjing , Zhang Hao , Wang Ling , Gu Weiying , Miao Yuqing , Liu Qinhua , Ouyang Changli , Zhu Junfeng , Wang Chunling , Zhu Taigang , Huang Shuiping , Sang Wei 

TITLE=The Addition of Ferritin Enhanced the Prognostic Value of International Prognostic Index in Diffuse Large B‐Cell Lymphoma

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.823079

DOI=10.3389/fonc.2021.823079

ISSN=2234-943X

ABSTRACT=Diffuse large B-cell lymphoma (DLBCL) is a highly heterogeneous non-Hodgkin lymphoma, and the prognosis of DLBCL patients is widely affected by multi-variables. Clinical factors based prognostic systems stratify the prognosis of DLBCL with certain limitations, and the value of ferritin on the prognosis of DLBCL is unclear. In this study, 225 cases were retrieved from 4 centers of Huaihai Lymphoma Working Group (HHLWG) as the derivation cohort, and 66 cases were from the other 6 centers of HHLWG as external validation cohort. X-Tile program divided ferritin into three groups when applying 175μg/L and 391.9 μg/L as the optimal cut-off points. Based on multivariable analysis, ferritin appeared to be a stronger predictor. A total of 3 variables (ferritin, age, and IPI) were included for the development of the nomogram. The C-indexes were 0.832 and 0.703 in the derivation and validation cohort and the calibration curve showed the consistency between the nomogram prediction and the actual observation. In conclusion, Ferritin based nomogram enhanced the prognostic value of IPI in DLBCL.