AUTHOR=Woeste Matthew R. , Wilson Khaleel D. , Kruse Edward J. , Weiss Matthew J. , Christein John D. , White Rebekah R. , Martin Robert C. G. 

TITLE=Optimizing Patient Selection for Irreversible Electroporation of Locally Advanced Pancreatic Cancer: Analyses of Survival

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2022

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.817220

DOI=10.3389/fonc.2021.817220

ISSN=2234-943X

ABSTRACT=Background:Irreversible electroporation(IRE) has emerged as a viable consolidative therapy after induction chemotherapy, in which this combination has improved overall survival of locally advanced pancreatic cancer(LAPC). Optimal timing and patient selection for irreversible electroporation remains a clinically unmet need. The aim of this study was to investigate preoperative factors that may assist in predicting progression-free and overall survival following IRE.
Methods:A multi-institutional, prospectively maintained database was reviewed for patients with LAPC treated with induction chemotherapy followed by open-technique irreversible electroporation from 7/2015-5/2019. RECIST 1.1 criteria were used to assess tumor response and radiological progression. Overall survival(OS) and progression-free survival(PFS) were recorded. Survival analyses were performed using Kaplan Meier and Cox multivariable regression analyses.   
Results: 187 LAPC patients(median age 62 years range, 21 – 91, 65% men, 35% women) were treated with IRE. Median PFS was 21.7 months and median OS from diagnosis was 25.5 months. On multivariable analysis, age