Front. Oncol. Frontiers in Oncology Front. Oncol. 2234-943X Frontiers Media S.A. 10.3389/fonc.2021.783320 Oncology Correction Corrigendum: CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment Jin Yue 1 2 3 4 † Che Xiaofang 1 2 3 4 † Qu Xiujuan 1 2 3 4 Li Xin 5 Lu Wenqing 1 2 3 4 Wu Jie 1 2 3 4 Wang Yizhe 1 2 3 4 Hou Kezuo 1 2 3 4 Li Ce 1 2 3 4 Zhang Xiaojie 1 2 3 4 Zhou Jianping 5 * Liu Yunpeng 1 2 3 4 * 1 Department of Medical Oncology, The First Hospital of China Medical University, Shenyang, China 2 Key Laboratory of Anticancer Drugs and Biotherapy of Liaoning Province, The First Hospital of China Medical University, Shenyang, China 3 Liaoning Province Clinical Research Center for Cancer, Shenyang, China 4 Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors, Ministry of Education, Shenyang, China 5 Department of Gastrointestinal Surgery, The First Hospital of China Medical University, Shenyang, China

Edited and reviewed by: Bin Li, Jinan University, China

*Correspondence: Jianping Zhou, zjphama@163.com; Yunpeng Liu, ypliu@cmu.edu.cn

†These authors have contributed equally to this work

This article was submitted to Gastrointestinal Cancers, a section of the journal Frontiers in Oncology

 12 11 2021 2021 11 783320 29 09 2021 29 10 2021 Copyright © 2021 Jin, Che, Qu, Li, Lu, Wu, Wang, Hou, Li, Zhang, Zhou and Liu 2021 Jin, Che, Qu, Li, Lu, Wu, Wang, Hou, Li, Zhang, Zhou and Liu

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 A Corrigendum on CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment By Jin Y, Che X, Qu X, Li X, Lu W, Wu J, Wang Y, Hou K, Li C, Zhang X, Zhou J and Liu Y (2020). Front. Oncol. 10:1612. doi: 10.3389/fonc.2020.01612 CircHIPK3 long-term hypoxic microenvironment HIF-2α gastric cancer metastasis

In the original article, there was a mistake in Figure 2D as published. The picture of migration of sicircHIPK3 in BGC823/Hypo cells in Figure 2D was misused. The corrected Figure 2 appears below.

The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

CircHIPK3 promoted migration and invasion of HRGC cells. (A) The sequence of two siRNAs targeted to back-splicing site of circHIPK3 and the negative control siRNA. (B, C) The relative expression of circHIPK3 and linear HIPK3 mRNA in HRGC cells after transfected with negative control siRNA (siNC) or circHIPK3 siRNAs was detected by qRT-PCR. 18S was used as an internal control. (D, E) The migration and invasion ability of HRGC cells after transfected with siNC or circHIPK3 siRNAs was examined by transwell assay (original magnification, 100×). The columns on the down panels are quantified by counting 3 fields, and presented as the mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001. (F) The overexpression efficiency of circHIPK3 in MGC803 and BGC823 cells was detected by qRT-PCR. 18S was used as an internal control. (G, H) The migration and invasion ability of MGC803 and BGC823 cells after transfected with circHIPK3 overexpression plasmids and empty vectors was examined by transwell assay (original magnification, 100×). The columns on the right are quantified by counting three fields, and presented as the mean ± standard deviation. *p < 0.05, **p < 0.01, ***p < 0.001. Data are presented as the mean ± SD of three independent experiments. *p < 0.05, **p < 0.01, ***p < 0.001.

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