AUTHOR=Zeng Ping , Si Meng , Sun Rui-xia , Cheng Xu , Li Xiao-yang , Chen Min-bin 

TITLE=Prognostic Value of CD9 in Solid Tumor: A Systematic Review and Meta-Analysis

JOURNAL=Frontiers in Oncology

VOLUME=Volume 11 - 2021

YEAR=2021

URL=https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2021.764630

DOI=10.3389/fonc.2021.764630

ISSN=2234-943X

ABSTRACT=Numerous clinical studies investigated low expression of CD9 predict poor prognosis of solid tumor. However, the results were inconclusive. This present meta-analysis was therefore performed to determine the prognostic value of CD9 expression in solid tumors. In this meta-analysis, 25 studies involving 5555 participants were included, the result showed that strong significant associations between declined expression of CD9 and all endpoints: overall survival (HR=1.88, 95%CI=1.45–2.43, P<.000), time to progression (HR=2.0, 95%CI=1.38-2.88, P<.000). The subgroup analysis was also performed, which revealed that the associations between CD9 down-regulated expression related to poor OS in lung cancer, head and neck cancer. As well, CD9 low-expression was significantly connected with poor TTP in patients with head and neck cancer. The adverse prognostic impact of decreased expression of CD9 was observed in patients of different ethnicities. In conclusion, these results showed that declined expression of CD9 was associated with poor survival in human solid tumors. CD9 may be a valuable prognosis predictive biomarker and a potential therapeutic target in human solid tumors.